Serum/plasma mass concentration of bile acids (total)

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like jaundice (yellowing of skin/eyes), abdominal pain, unexplained fatigue, or if they suspect liver disease, gallbladder issues, or bile duct blockage. It can also help diagnose conditions like cirrhosis, hepatitis, or bile acid malabsorption.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if your lab requires it, but always follow your provider’s instructions. Bring any medications you’re taking, as some may affect results.

How the Test Works

A blood sample is drawn from a vein in your arm. The sample is sent to a lab where bile acids are measured using a specialized analytical method, often high-performance liquid chromatography (HPLC). Results are reported in micrograms per deciliter (mcg/dL) or similar units.

What the Results Mean

Higher-than-normal levels may suggest liver disease, gallbladder problems, or bile duct obstructions. Lower-than-normal levels could indicate bile acid malabsorption or certain metabolic disorders. Your provider will interpret results in the context of your symptoms and medical history.