Serum/plasma globulin protein concentration (total)
This test measures the amount of globulin proteins in your blood, which helps assess overall protein balance and potential immune or liver function issues.
["Globulins support immunity, transport substances, and maintain blood clotting—your levels can signal hidden health concerns."]
Key facts at a glance
- LOINC
- 892-0
- Short code
- ABSCRN3
- Synonyms
- Bld gp Ab Scn Cell III SerPl Ql
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or plain red-top tube; EDTA plasma tube acceptable for some platforms
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 0 years
- Method
- blood-group-antibody-screen
- CPT
- 86850
- SNOMED
- 249191000124108
- Specimen volume
- 3-5 mL whole blood (yielding at least 1-2 mL serum or plasma)
- Stability
- Serum/plasma stable for 72 hours at 2-8°C; frozen at -20°C or colder for long-term storage up to 6 months. Do not freeze whole blood.
- Hemolysis max
- 100
- Lipemia max
- 500
- Icterus max
- 40
- TAT
- 2–24 hours
- Order
- routine
What Globulins Do in Your Body
Globulins are a group of proteins in your blood that include antibodies (for immunity), transport proteins (like lipoproteins), and others that help regulate blood clotting and fluid balance. While albumin is the most abundant protein, globulins play a key role in immune defense and long-term health.
Why It Matters for Your Health
Abnormal globulin levels may indicate conditions like chronic inflammation, liver disease, or immune disorders. High levels could suggest overactive immune responses or liver issues, while low levels might point to malnutrition or protein loss.
Common Reasons for Testing
Your doctor may order this test if you have symptoms like fatigue, swelling, frequent infections, or unexplained weight changes. It’s also used to monitor conditions like multiple myeloma, liver disease, or autoimmune disorders.
Sample Collection & Preparation
A blood sample is drawn from your arm, and the serum or plasma is separated for testing. No special preparation is needed, but fasting may be advised depending on your specific test order.
Reference range
Negative (no clinically significant alloantibodies detected against screening cells I, II, and III)N/A
No fasting required. Patients should inform their healthcare provider about any prior blood transfusions, pregnancies, or history of hemolytic transfusion reactions. Sample should be drawn prior to administering blood products when possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Total Globulin Level
Frequently asked questions
What could my results mean?
Do I need to prepare for this test?
How long will it take to get my results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy