Skip to content

Breast Cancer Recurrence Risk Analysis Score, Tissue

Published: August 9, 2026Updated: August 17, 2026

A tumor-tissue test that estimates the likelihood of breast cancer returning and may help guide decisions about additional treatment.

Quick summary

["This test estimates breast cancer recurrence risk from tumor tissue to help guide treatment planning."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
104119-3
Short code
Breast Ca recurrence risk anlyss tiss
Synonyms
Breast Ca recurrence risk anlyss tiss
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This laboratory test examines information from breast cancer tissue, often a molecular gene-expression profile, to estimate the likelihood that the cancer may return. It is generally used after a breast cancer biopsy or surgery.

Why might I need this test?

The result may help your oncology team assess recurrence risk and decide whether additional treatments, such as endocrine therapy or chemotherapy, are likely to be beneficial. It is considered along with the tumor’s stage, hormone-receptor status, other pathology findings, and your overall health.

How is the test performed?

A pathology laboratory uses suitable tumor tissue from a biopsy or surgical specimen. Specialized laboratory methods generate a recurrence-risk result, which is interpreted together with your other cancer information.

How do I prepare for the test?

No special preparation is usually needed because the test is performed on stored tissue rather than a new blood sample. Your care team should confirm that adequate tumor tissue is available and discuss timing, insurance coverage, and whether testing will delay treatment.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Breast cancer recurrence risk score

Frequently asked questions

Does a high-risk result mean the cancer will definitely return?
No. It estimates the likelihood of recurrence based on tumor characteristics; it cannot guarantee whether or when the cancer will return.
Does this test replace staging or other breast cancer tests?
No. It is interpreted with tumor stage, hormone-receptor and HER2 status, pathology findings, and your overall health.
Is a biopsy or surgery required specifically for this test?
The test usually uses tissue collected during an earlier biopsy or surgery. Ask your oncology team whether suitable tissue is already available.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy