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Bupropion concentration in serum/plasma (quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of the antidepressant bupropion in your blood. It helps doctors check if your medication is working as intended or if adjustments are needed.

Quick summary

["This test helps monitor your antidepressant therapy levels safely and effectively."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73496-2
Short code
buPROPion ind plt IgG SerPl Ql FC
Synonyms
buPROPion ind plt IgG SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re taking bupropion (such as Wellbutrin) to ensure your medication levels are within the recommended range. It’s particularly useful for patients who experience side effects, have difficulty sticking to their medication schedule, or are being treated for conditions like depression or ADHD.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm or vein to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Test Results Mean

Results are typically reported in micrograms per milliliter (µg/mL) or nanograms per milliliter (ng/mL). While reference ranges vary by lab, lower-than-expected levels may indicate insufficient medication, while higher-than-expected levels could signal toxicity or improper metabolism.

Possible Side Effects or Considerations

Bupropion is generally well-tolerated, but very high levels can cause serious side effects like seizures, confusion, or rapid heartbeat. Your provider will review your results closely and adjust your dose if needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Bupropion Level

Frequently asked questions

What does a low bupropion level mean?
A low level may mean your medication isn’t working as expected, or you may need to take it more frequently or at different times. Your doctor might suggest increasing your dose or checking for adherence issues.
What does a high bupropion level mean?
High levels could indicate improper metabolism, drug interactions, or overdose. Seek medical attention immediately if you experience symptoms like dizziness, seizures, or irregular heartbeat.
How often should I get this test?
Your provider will determine the timing based on your treatment plan, but tests are often done 2–4 weeks after starting or adjusting your dose to assess stability.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy