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Butyrylglycine (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the concentration of butyrylglycine, a naturally occurring compound in your blood that may be linked to certain metabolic or genetic conditions.

Quick summary

["Butyrylglycine levels can help assess potential metabolic or genetic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
24437-6
Short code
Butyrylgly/Creat Ur-sRto
Synonyms
Butyrylgly/Creat Ur-sRto
Category
glucose
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or risk factors for conditions like organic acidemias, mitochondrial disorders, or other metabolic diseases. It may also be part of a broader evaluation for unexplained metabolic issues or genetic testing.

What to Expect Before the Test

No special preparation is typically needed. You may be asked to fast for a certain period if your blood is drawn early in the morning, but this depends on your provider’s instructions. Bring any medications or supplements you’re currently taking to your appointment.

How the Test Is Performed

A healthcare professional will collect a blood sample from a vein in your arm using a small needle. The blood will be sent to a lab for analysis. The specimen is usually processed as serum or plasma.

What the Results Mean

Results are interpreted by your healthcare provider based on your clinical picture, symptoms, and other test results. Elevated or low levels may indicate specific metabolic or genetic conditions that require further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Butyrylglycine is an intermediate metabolite in the breakdown of certain amino acids and fatty acids. Abnormal levels can suggest underlying metabolic disorders, such as defects in enzymes responsible for processing organic acids. This test is particularly useful in diagnosing conditions like methylmalonic acidemia or propionic acidemia, among others. Your provider will use these results to guide further testing or treatment plans.

Short name

Butyrylglycine Level

Frequently asked questions

What causes butyrylglycine levels to be tested?
Butyrylglycine levels are often tested when a healthcare provider suspects a metabolic disorder, especially in individuals with symptoms such as vomiting, weakness, developmental delays, or unexplained metabolic acidosis. It may also be part of genetic testing or evaluation for conditions linked to organic acidemias.
What are common symptoms associated with abnormal butyrylglycine levels?
Symptoms may include persistent vomiting, lethargy, poor growth or development, seizures, or respiratory issues. However, symptoms can vary widely depending on the underlying cause. Some individuals may not show symptoms at all.
How are butyrylglycine levels typically treated?
Treatment depends on the specific metabolic disorder diagnosed. This may include dietary modifications, medications to manage symptoms, or enzyme replacement therapy. Early and accurate diagnosis is crucial for effective management.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy