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Complete Blood Count with Differential (CBC with Differential)

Published: August 9, 2026Updated: August 17, 2026

This test measures your blood’s overall health, including red blood cells, white blood cells, and platelets, along with the proportions of different types of white blood cells.

Quick summary

["A CBC helps diagnose and monitor conditions like anemia, infections, or blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
4490-9
Short code
C3b-C4b Recep EntNum RBC
Synonyms
C3b-C4b Recep EntNum RBC
Category
coagulation
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does the CBC Measure?

Your blood is analyzed for several key components: **Red Blood Cells (RBCs)** – carry oxygen to your body’s tissues; **White Blood Cells (WBCs)** – fight infections and inflammation; and **Platelets** – help your blood clot. The differential count breaks down the types of white blood cells (neutrophils, lymphocytes, monocytes, eosinophils, basophils) to identify specific health concerns.

Why Might You Need This Test?

A CBC is often the first test doctors use to check for signs of anemia, infections, bleeding disorders, or other blood-related issues. It can also help monitor chronic conditions like diabetes, kidney disease, or cancer.

How Is the Test Performed?

A small blood sample is taken from your arm or finger. The blood is then examined under a microscope to count and identify the different cell types. Some labs may use automated machines to analyze the sample quickly and accurately.

What Are Common Results and Their Meanings?

Low RBCs or hemoglobin may indicate anemia, while high RBCs could suggest dehydration or other conditions. Low platelets may signal bleeding disorders, and high platelet counts might point to conditions like cancer or infection. The differential helps pinpoint whether an infection is viral, bacterial, or another type.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: whole-blood

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CBC with Differential

Frequently asked questions

What Are the Normal Values for This Test?
Normal values vary by lab and age, so your results will be compared to your specific baseline or reference ranges provided by your healthcare provider.
How Long Does It Take to Get Results?
Results are typically available within 1–2 business days, depending on your lab’s processing time.
Can I Eat or Drink Before This Test?
No special preparation is needed, but inform your doctor about any medications or supplements you’re taking, as they may affect results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy