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Complete Blood Count with Differential (CBC with Differential)

Published: August 9, 2026Updated: August 17, 2026

This test measures your blood’s overall health, including red blood cells, white blood cells, and platelets, along with the proportions of different types of white blood cells.

Quick summary

["A CBC helps doctors diagnose and monitor conditions like anemia, infections, or blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
6296-8
Short code
C3b-C4b Recep RBC Ql
Synonyms
C3b-C4b Recep RBC Ql
Category
coagulation
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does a CBC Measure?

A CBC evaluates several key components of your blood: - **Red blood cells (RBCs):** Carry oxygen to tissues. - **Hemoglobin:** The protein in RBCs that transports oxygen. - **Hematocrit:** The percentage of blood volume made up of RBCs. - **Platelets:** Help with blood clotting. - **White blood cells (WBCs):** Fight infections and inflammation. - **Differential count:** The breakdown of WBC types (e.g., neutrophils, lymphocytes).

Why Might You Need a CBC?

Doctors order a CBC to check for signs of: - Anemia (low RBCs or hemoglobin). - Infections (e.g., high WBCs). - Blood disorders (e.g., leukemia, thrombocytopenia). - Kidney or liver issues (indirectly, through RBC/protein levels).

How Is a CBC Performed?

A small blood sample is drawn from a vein (usually in your arm). The sample is sent to a lab, where machines analyze it for RBCs, WBCs, platelets, and their proportions. No special preparation is needed, but fasting isn’t required for this test alone.

What Are Common Results?

Results may show: - **Low RBCs/hemoglobin:** Possible anemia. - **High WBCs:** Possible infection or inflammation. - **Low platelets:** Risk of bleeding. - **Abnormal WBC differential:** Could signal immune issues or other conditions.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: whole-blood

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CBC with Differential

Frequently asked questions

How often do I need a CBC?
What do my CBC results mean?
Can I prepare for a CBC?
What if my CBC shows unusual results?
Does a CBC hurt?
The blood draw itself may cause mild discomfort, but most people tolerate it well. A small bandage is applied afterward to prevent bruising. If you’re nervous, ask your doctor about numbing cream.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy