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Cadmium in Serum (Mass Concentration)

Published: August 9, 2026Updated: August 10, 2026

This test measures the amount of cadmium, a heavy metal, present in your blood serum. Cadmium exposure can occur from environmental sources like industrial processes, smoking, or contaminated food/water.

Quick summary

["Cadmium levels help assess potential exposure risks and long-term health effects."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 10, 2026Editorial policy

Key facts at a glance

LOINC
21129-2
Short code
CD
Synonyms
Cadmium SerPl-mCnc
Category
chemistry
Sample
serum
Container
Royal blue-top (trace element) vacutainer tube, no anticoagulant for serum; or royal blue-top EDTA tube for plasma
Units
N/A
Ref low
0
Ref high
5
Critical range
— – 50 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–99 years
Method
Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
CPT
82300
SNOMED
396751005
Specimen volume
2 mL serum or plasma
Stability
Room temperature: 7 days; Refrigerated (2-8°C): 14 days; Frozen (-20°C): 30 days
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like chronic kidney disease, nausea, weakness, or if you’ve been exposed to cadmium through work, smoking, or other environmental hazards. It may also be part of routine monitoring for certain occupations or conditions.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the draw if instructed by your provider. Wear comfortable clothing and bring any medications you’re currently taking.

What the Test Involves

A healthcare professional will draw blood from a vein in your arm. The sample is then sent to a lab for analysis using advanced techniques to measure cadmium concentration.

What the Results Mean

Results are compared to reference ranges specific to your lab. High levels may indicate exposure or toxicity, while low levels suggest minimal risk. Your provider will discuss results in the context of your health history and symptoms.

Reference range

Non-smokers: <0.5 µg/L; Smokers: <1.5 µg/L; OSHA biological exposure limit: <5 µg/LN/A

Specimen: serum

No fasting required. Avoid smoking and seafood consumption for 48 hours prior to collection. Inform clinician of any occupational exposure to heavy metals.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cadmium Level

Frequently asked questions

How is cadmium absorbed or removed from the body?
Cadmium is primarily absorbed through the lungs (e.g., from smoking) or digestive tract (e.g., contaminated food). The body does not efficiently excrete cadmium; it accumulates over time in organs like the kidneys and liver.
What are common sources of cadmium exposure?
Industrial settings (e.g., battery manufacturing), smoking cigarettes, eating certain foods (e.g., shellfish, leafy greens), and drinking water from contaminated sources are common sources. Occupational exposure is a major risk for workers in these fields.
Can diet alone reduce cadmium levels?
While diet alone may not lower cadmium levels significantly, reducing intake of high-cadmium foods (e.g., certain types of fish) and avoiding smoking can help lower exposure. Chelation therapy (rarely used) may be considered for severe toxicity under medical supervision.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 10, 2026. · Read our editorial policy