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C-reactive protein (high-sensitivity) concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein produced by your liver in response to inflammation, helping doctors assess low-level inflammation in your body.

Quick summary

["hsCRP helps track subtle inflammation that may not show up in other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23685-1
Short code
CAV1NA
Synonyms
CAdV1 NAb Ser Ql Nt
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top tube without anticoagulant
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
Virus neutralization test (VNT)
SNOMED
122580008
Specimen volume
1-2 mL of serum
Stability
Stable for 7 days at 2-8°C; for longer storage, freeze at -20°C or below
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
48–168 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to monitor chronic conditions like heart disease, arthritis, or metabolic disorders, or to check for early signs of inflammation after surgery, injury, or infection.

What Does a High or Low Result Mean?

Elevated levels may indicate inflammation, infection, or autoimmune conditions, while very low levels might suggest suppressed immune response or certain medications affecting inflammation.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed using a sensitive immunoassay method to detect the protein.

What Should You Know Before Testing?

Avoid strenuous exercise or consuming anti-inflammatory foods (like turmeric) 24 hours before testing for more accurate results. Fasting is not required.

Reference range

Antibody titer reported as positive or negative. Protective titer typically >=1:16 to >=1:32 depending on laboratory and reference standards.N/A

Specimen: serum

No special preparation required. Sample collection may be performed without fasting.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hsCRP

Frequently asked questions

What causes elevated hsCRP levels?
Elevated hsCRP can result from infections, autoimmune diseases (like rheumatoid arthritis), chronic conditions (e.g., diabetes), or stress. It may also be influenced by genetics or lifestyle factors.
Can lifestyle changes affect hsCRP levels?
Yes, diet, exercise, and weight management can lower inflammation. Smoking, obesity, and poor sleep may raise levels, so small changes can help track improvement over time.
How often should I get this test?
Your doctor will determine frequency based on your health needs—some patients get it yearly for monitoring, while others may need it more often if managing a specific condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy