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Candida albicans Antibody, Titration (Serum)

Published: August 9, 2026Updated: August 15, 2026

This test measures the level of antibodies your body produces in response to *Candida albicans*, a type of yeast commonly found in the mouth, gut, and skin. It helps assess immune response to this fungus.

Quick summary

["This test helps doctors evaluate if your immune system is reacting to *Candida albicans* and may support diagnosis of fungal infections or immune-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
42859-9
Short code
CANDAB
Synonyms
C albicans Ab Titr Ser
Category
chemistry
Sample
serum
Container
Serum separator tube (SST, gold top); Red top tube acceptable
Units
N/A
Ref low
10
Ref high
1
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
Enzyme-linked immunosorbent assay (ELISA); Complement fixation; Immunodiffusion
CPT
86645
SNOMED
43151009
Specimen volume
1-2 mL serum
Stability
Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days. Avoid repeated freeze-thaw cycles.
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

What This Test Measures

The test detects specific antibodies (immunoglobulins) your immune system creates when exposed to *Candida albicans*. These antibodies are part of your body’s defense mechanism against fungal infections. The titration process determines the exact concentration of these antibodies, which can vary depending on exposure and immune response.

Why It Might Be Ordered

A healthcare provider may order this test if you have symptoms like persistent oral thrush, recurrent fungal infections, or if you’re undergoing treatment that weakens your immune system (e.g., chemotherapy, long-term steroids). It can also be used to monitor immune function in certain conditions.

Sample Collection and Preparation

Blood is drawn from a vein in your arm, and the serum (liquid part of blood after clotting) is separated for testing. The sample is then analyzed to measure antibody levels through a specialized immunoassay method.

What to Expect Before the Test

No special preparation is needed, but inform your doctor about any medications (especially immunosuppressants) or recent infections that could affect results. Avoid alcohol for 24 hours before testing if possible.

Reference range

Titer <1:10 or negative: No significant antibodies detected. Titer 1:10-1:40: Low/equivocal result suggesting past exposure. Titer ≥1:80: Positive result suggestive of active or recent Candida albicans infection. Titers may persist for months following resolved infection.N/A

Specimen: serum

No fasting required. Patients on antifungal therapy may have altered results; document recent antifungal use. Specimen should be collected prior to initiation of antifungal therapy when possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated antibody levels may indicate past or current exposure to *Candida albicans*, suggesting an immune response to the fungus. However, antibody levels alone don’t confirm an active infection—they may be normal even if you have symptoms. This test is often used alongside other diagnostic tools (like cultures or imaging) to guide treatment decisions.

Short name

Candida Antibody Titration

Frequently asked questions

What does a high or low antibody level mean?
A high antibody level suggests your immune system has recognized *Candida albicans* and produced antibodies in response, which could mean past exposure or a chronic immune reaction. However, it doesn’t always mean you have an active infection. Low levels may indicate limited exposure or immune suppression.
Can this test diagnose a fungal infection?
No, this test alone cannot diagnose a fungal infection. It measures antibodies, not live yeast. Doctors typically use this test in combination with clinical symptoms, cultures, or other diagnostic tests (like a fungal blood test or skin biopsy) for accurate diagnosis.
How often should I get this test?
The frequency depends on your medical condition and treatment plan. Your doctor will determine if repeat testing is needed, especially if you’re on long-term antifungal therapy or have a history of recurrent infections.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy