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Calcitonin, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

A blood test that measures calcitonin, a hormone mainly produced by thyroid C cells, to help evaluate thyroid conditions and calcium-related abnormalities.

Quick summary

["Elevated calcitonin may indicate increased thyroid C-cell activity, while low levels are generally less concerning."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50183-3
Short code
Calcit 1M p CPG IV SerPl-mCnc
Synonyms
Calcit 1M p CPG IV SerPl-mCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures the concentration of calcitonin in serum or plasma. Calcitonin is a hormone produced mainly by specialized cells in the thyroid called C cells.

Why might I need this test?

Calcitonin may be measured to evaluate thyroid nodules, possible medullary thyroid carcinoma, and persistent or recurrent hypercalcemia. It may also be used to monitor certain thyroid conditions over time.

How is the test performed?

A blood sample is collected, and the laboratory measures calcitonin using an immunoassay or another validated laboratory method. The result is usually reported as a concentration in the blood.

How do I prepare for the test?

No special preparation is usually required. Follow your clinician's instructions, particularly if you have been told to fast or if the test is being repeated for monitoring.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A higher-than-expected calcitonin level can occur with thyroid C-cell tumors, including medullary thyroid carcinoma, but it may also result from benign thyroid conditions or elevated blood calcium. Interpretation depends on the clinical situation and other thyroid tests, and an abnormal result usually requires further evaluation.

Short name

Calcitonin

Frequently asked questions

Is calcitonin the same as calcium?
No. Calcitonin is a thyroid hormone that helps regulate calcium levels, while calcium is a mineral measured by a separate blood test.
Does an elevated calcitonin result mean I have thyroid cancer?
No. Elevated calcitonin can have several causes, including benign thyroid conditions, high blood calcium, and less commonly thyroid C-cell tumors. Additional testing is needed to determine the cause.
Do I need to fast before this test?
Fasting is not generally required, but your clinician may request it in certain situations. Follow the specific instructions provided with your test order.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy