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Calcium in Serum or Plasma (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of calcium present in your blood, which is important for maintaining healthy bones, muscles, and nerves.

Quick summary

["Blood calcium levels help assess bone health and nerve function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47369-4
Short code
CALC-BF
Synonyms
Calcit Fld-mCnc
Category
chemistry
Sample
serum
Container
Red-top serum tube or serum separator tube (SST)
Units
N/A
Ref low
0
Ref high
11.5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Chemiluminescent Immunoassay (CLIA)
CPT
82308
SNOMED
39579005
Specimen volume
1-2 mL of serum
Stability
Stable for 8 hours at room temperature; refrigerated (2-8°C) for up to 48 hours; frozen (-20°C or below) for up to 3 months. Avoid repeated freeze-thaw cycles.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like low or high calcium levels, which can cause symptoms such as muscle cramps, weakness, or irregular heartbeats. It may also be used to monitor conditions like kidney disease, osteoporosis, or certain cancers that affect calcium metabolism.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it involves drawing blood from a vein, but this is not always required. Bring any medications or supplements you’re taking, as they can affect results.

What Happens During the Test?

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The blood sample is then sent to a lab for analysis.

What Are Possible Results?

Results are typically reported in milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L). Your provider will interpret the results in relation to your overall health and symptoms.

Reference range

Reference ranges vary by laboratory, assay methodology, and specimen type. For serum: Male: <11.5 pg/mL; Female: <4.6 pg/mL. For body fluid values, interpret in clinical context.N/A

Specimen: serum

No special patient preparation required. Some clinicians may prefer a fasting sample to minimize interference from recent food intake.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum/Plasma Calcium

Frequently asked questions

What causes low calcium levels?
Low calcium (hypocalcemia) can result from conditions like vitamin D deficiency, kidney problems, or certain medications. It may also occur after surgery, severe burns, or prolonged vomiting/diarrhea. Symptoms can include muscle spasms, numbness, or irregular heartbeat.
What causes high calcium levels?
High calcium (hypercalcemia) is often linked to overactive thyroid, kidney issues, or cancers that produce abnormal hormones. It may also occur from prolonged use of certain medications or excessive vitamin D intake. Symptoms can include fatigue, nausea, or kidney stones.
How often should I get this test?
Your provider will determine frequency based on your health status. Routine adults may not need calcium tests unless they have risk factors (e.g., kidney disease, osteoporosis). Follow-up may be scheduled if you have a diagnosed condition affecting calcium metabolism.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy