Serum/plasma mass concentration of cancer-associated protein (e.g., tumor marker)
This test measures the amount of a protein in your blood that may be linked to certain cancers. It helps doctors check for signs of cancer or monitor treatment progress.
["Assists in cancer detection or evaluation of treatment response."]
Key facts at a glance
- LOINC
- 19189-0
- Short code
- CA549
- Synonyms
- Cancer Ag549 SerPl-aCnc
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or red-top tube
- Units
- N/A
- Ref low
- 0
- Ref high
- 11
- Critical range
- 0.5 N/A – —
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 18 years
- Method
- Immunoassay
- CPT
- 86316
- SNOMED
- 395129003
- Specimen volume
- 1 mL serum
- Stability
- Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C): 3 months
- Hemolysis max
- 100
- Lipemia max
- 100
- Icterus max
- 50
- TAT
- 24–72 hours
- Order
- routine
Your doctor may order this test if you have symptoms that need a closer look, if you have a condition that requires regular monitoring, or as part of a routine checkup to screen for early signs of illness. It can help confirm or rule out a diagnosis, track how well a treatment is working, and guide decisions about your ongoing care.
Your doctor may recommend this test if you have symptoms of cancer, a history of cancer, or if you’re undergoing cancer screening or treatment. It can also be used to monitor conditions like certain types of tumors or to evaluate your body’s response to therapy.
Before the test, your care team will give you specific instructions to follow. You may be asked to fast for a certain number of hours, avoid certain foods, drinks, or medications, and drink plenty of water. Let your doctor know about all prescriptions, over-the-counter drugs, and supplements you take, since some of these can affect your results.
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it involves a blood draw. Avoid strenuous activity or smoking for a few hours beforehand. Hydration is important, but drink only water unless instructed otherwise.
The test usually involves collecting a small sample, most often blood drawn from a vein in your arm, although some tests use urine, saliva, or a finger stick instead. The sample is sent to a laboratory, where trained staff and specialized equipment measure the substances your doctor wants to evaluate, and the finished report is sent back to your care team.
A blood sample is taken from a vein in your arm. The blood is then processed to separate the serum or plasma, where the protein is measured using advanced laboratory techniques. The test detects the protein’s concentration to assess its potential clinical relevance.
Your results are typically compared with a reference range, which is the interval considered normal for healthy people. A value within that range is generally reassuring, while a result above or below it may point to infection, inflammation, organ stress, or another condition that needs attention. Your doctor will interpret your numbers together with your symptoms, medical history, and other tests before recommending next steps.
Results may vary depending on the protein being tested and your medical history. Elevated levels might suggest cancer presence, but they can also be influenced by other health conditions or medications. Your doctor will interpret the results in the context of your overall health and symptoms.
Reference range
Normal: < 11 U/mL; Borderline: 11-15 U/mL; Elevated: > 15 U/mLN/A
No fasting required. Specimen collection is not affected by recent food intake. Patients should follow standard phlebotomy preparation guidelines.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Cancer marker screening (serum/plasma)
Frequently asked questions
This test helps identify proteins associated with specific cancers, such as prostate, breast, or ovarian cancers, among others. While not all elevated markers indicate cancer, they can signal the need for further testing or guide treatment decisions. It’s important to discuss results with your healthcare provider.
An elevated result may raise concerns about cancer or other health issues, but it doesn’t confirm a diagnosis alone. Your doctor will review the results alongside other tests, medical history, and symptoms to determine the next steps. Low levels may not indicate cancer but could be normal for your body.
Some lifestyle factors, like diet, exercise, or certain medications, might influence protein levels. However, the impact varies by protein and individual health. Always follow your doctor’s advice regarding test preparation and lifestyle adjustments.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy