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Serum/plasma mass concentration of cancer-associated protein (e.g., tumor marker)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of a protein in your blood that may be linked to certain cancers. It helps doctors check for signs of cancer or monitor treatment progress.

Quick summary

["Assists in cancer detection or evaluation of treatment response."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
19189-0
Short code
CA549
Synonyms
Cancer Ag549 SerPl-aCnc
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top tube
Units
N/A
Ref low
0
Ref high
11
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
≥ 18 years
Method
Immunoassay
CPT
86316
SNOMED
395129003
Specimen volume
1 mL serum
Stability
Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C): 3 months
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

Your doctor may order this test if you have symptoms that need a closer look, if you have a condition that requires regular monitoring, or as part of a routine checkup to screen for early signs of illness. It can help confirm or rule out a diagnosis, track how well a treatment is working, and guide decisions about your ongoing care.

Your doctor may recommend this test if you have symptoms of cancer, a history of cancer, or if you’re undergoing cancer screening or treatment. It can also be used to monitor conditions like certain types of tumors or to evaluate your body’s response to therapy.

Before the test, your care team will give you specific instructions to follow. You may be asked to fast for a certain number of hours, avoid certain foods, drinks, or medications, and drink plenty of water. Let your doctor know about all prescriptions, over-the-counter drugs, and supplements you take, since some of these can affect your results.

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it involves a blood draw. Avoid strenuous activity or smoking for a few hours beforehand. Hydration is important, but drink only water unless instructed otherwise.

The test usually involves collecting a small sample, most often blood drawn from a vein in your arm, although some tests use urine, saliva, or a finger stick instead. The sample is sent to a laboratory, where trained staff and specialized equipment measure the substances your doctor wants to evaluate, and the finished report is sent back to your care team.

A blood sample is taken from a vein in your arm. The blood is then processed to separate the serum or plasma, where the protein is measured using advanced laboratory techniques. The test detects the protein’s concentration to assess its potential clinical relevance.

Your results are typically compared with a reference range, which is the interval considered normal for healthy people. A value within that range is generally reassuring, while a result above or below it may point to infection, inflammation, organ stress, or another condition that needs attention. Your doctor will interpret your numbers together with your symptoms, medical history, and other tests before recommending next steps.

Results may vary depending on the protein being tested and your medical history. Elevated levels might suggest cancer presence, but they can also be influenced by other health conditions or medications. Your doctor will interpret the results in the context of your overall health and symptoms.

Reference range

Normal: < 11 U/mL; Borderline: 11-15 U/mL; Elevated: > 15 U/mLN/A

Specimen: serum

No fasting required. Specimen collection is not affected by recent food intake. Patients should follow standard phlebotomy preparation guidelines.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Cancer marker screening (serum/plasma)

Frequently asked questions

This test helps identify proteins associated with specific cancers, such as prostate, breast, or ovarian cancers, among others. While not all elevated markers indicate cancer, they can signal the need for further testing or guide treatment decisions. It’s important to discuss results with your healthcare provider.
What does it mean if my result comes back higher or lower than the normal range?
An elevated result may raise concerns about cancer or other health issues, but it doesn’t confirm a diagnosis alone. Your doctor will review the results alongside other tests, medical history, and symptoms to determine the next steps. Low levels may not indicate cancer but could be normal for your body.
An abnormal result does not automatically mean you are seriously ill, but it does signal that something deserves a closer look. Your doctor may repeat the test or order additional studies to find the cause, so bring any questions to your follow-up visit.
Some lifestyle factors, like diet, exercise, or certain medications, might influence protein levels. However, the impact varies by protein and individual health. Always follow your doctor’s advice regarding test preparation and lifestyle adjustments.
Frequency depends on your medical condition, treatment plan, and doctor’s recommendations. Some patients may need this test annually or more often if they have a history of cancer or are undergoing active treatment. Your doctor will outline the schedule based on your needs.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy