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Tissue-specific cancer antigen 724 (TCA-724) immunoassay

Published: August 9, 2026Updated: August 17, 2026

This test measures a protein found in certain types of cancerous tissues, including some breast, lung, and colorectal cancers. It may be used as part of a broader cancer screening or monitoring panel.

Quick summary

["A blood test to detect or track certain cancers by measuring a protein unique to specific tissue types."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
47012-0
Short code
CA72-4-IHC
Synonyms
Cancer Ag72-4 Tiss Ql ImStn
Category
chemistry
Sample
serum
Container
Formalin-fixed, paraffin-embedded (FFPE) tissue block or unstained tissue slides
Units
N/A
Ref low
72
Ref high
4
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-stain
CPT
88342
SNOMED
108671000119105
Specimen volume
Tissue block or 4-5 micron thick unstained paraffin sections mounted on positively charged slides; minimum 1 slide for IHC staining
Stability
FFPE tissue blocks are stable indefinitely at room temperature. Unstained paraffin sections are stable for up to 6 months at 2-8°C. Cut sections should be stained within 2 weeks for optimal antigen preservation.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
48–72 hours
Order
routine

What Is TCA-724 Used For?

TCA-724 is primarily used in conjunction with other diagnostic tests to help identify or monitor certain cancers. It may be ordered during cancer screening, especially in high-risk patients, or as part of follow-up care to assess treatment response or recurrence. Some healthcare providers may also use it in research settings to study cancer biology.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is then processed and analyzed in a laboratory using an immunoassay method to detect the presence of TCA-724 protein. This test does not require fasting or special preparation beyond standard blood draw procedures.

What Are Possible Results?

Results may indicate elevated levels of TCA-724, which could suggest the presence of cancerous tissue in certain organs. However, elevated levels alone are not definitive for cancer diagnosis. Your healthcare provider will interpret results in the context of your medical history, symptoms, and other tests.

What Does a Positive or Negative Result Mean?

A positive result (elevated TCA-724) may prompt further diagnostic testing, such as imaging, biopsies, or additional blood tests, to determine the cause. A negative result means no detectable TCA-724 protein was found in this sample, but it does not rule out cancer entirely. Other factors, like test sensitivity and patient-specific conditions, may influence results.

Reference range

Presence or absence of Cancer Ag 72-4 (TAG-72) antigen expression in tissue; results reported as positive or negative with staining intensity and percentage of cells stainedN/A

Specimen: serum

No fasting required. No special patient preparation needed for tissue specimens. Surgical or biopsy tissue handling should follow standard histopathology protocols with proper fixation in 10% neutral buffered formalin.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: TCA-724 in Cancer Detection and Monitoring

Short name

TCA-724 Blood Test

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend TCA-724 testing if you have a history of certain cancers, are at high risk for cancer, or are undergoing cancer treatment. It may also be used in research studies or as part of a multi-test panel to support diagnostic decisions. Always discuss the reason for testing with your healthcare provider.
Can this test replace other diagnostic tests?
No, TCA-724 is one tool among many used in cancer diagnosis and monitoring. It is not a standalone test and should be interpreted alongside other tests, imaging, and clinical findings. Your doctor will determine the most appropriate approach based on your situation.
What should I expect before or after the test?
No special preparation is needed before the test. You may experience mild discomfort or bruising at the blood draw site, but this usually resolves quickly. Results may take several days to a week to be reported, depending on lab processing times. Follow up with your doctor about next steps if you have concerns.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy