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Candida Antigen in Serum (Quantitative)

Published: August 9, 2026Updated: August 15, 2026

This test measures the presence of fungal antigens from *Candida* species in your blood serum, helping detect infections caused by yeast like *Candida albicans*.

Quick summary

["Detects yeast infections early with a simple blood test."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
9500-0
Short code
CANDM
Synonyms
Candida IgM Ser-aCnc
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top tube without anticoagulant
Units
N/A
Ref low
9
Ref high
11
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Enzyme-linked immunosorbent assay (ELISA) or chemiluminescent immunoassay (CLIA) for detection of IgM antibodies
CPT
86645
SNOMED
122216009
Specimen volume
1-2 mL of serum (minimum 0.5 mL)
Stability
Stable at room temperature for 8 hours; refrigerated (2-8°C) for 7 days; frozen (-20°C or below) for up to 30 days. Avoid repeated freeze-thaw cycles.
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

What Does This Test Measure?

The test identifies specific antigens produced by *Candida* yeast organisms, which may be released into your bloodstream when an infection is present. This is different from blood cultures, which look for live yeast cells.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like fever, mouth sores, or persistent thrush, especially if you have a weakened immune system, recent surgery, or a history of long-term medical conditions.

Who Should Consider This Test?

People at higher risk of *Candida* infections, such as those with diabetes, HIV/AIDS, cancer, or undergoing chemotherapy, may benefit from this test. It’s also used in patients with unexplained fevers or infections that don’t respond to antibiotics.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into a vein (usually in your arm) to draw blood. The process takes about 5 minutes, and you may feel slight discomfort.

Reference range

Negative: < 9 U/mL; Equivocal: 9-11 U/mL; Positive: > 11 U/mL. Reference ranges may vary by laboratory and assay manufacturer.N/A

Specimen: serum

No special preparation required. Sample can be collected at any time of day.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Candida Antigen Test

Frequently asked questions

How accurate is this test?
This test is highly sensitive for detecting *Candida* antigens in the blood, but it’s not definitive on its own. Results may be confirmed with additional tests, such as blood cultures or other imaging studies, depending on symptoms and clinical context.
Can false positives or negatives occur?
False positives are rare but possible, especially if you have recent antibiotic use or other infections. False negatives can happen if the infection isn’t severe enough or if the yeast hasn’t spread to the bloodstream yet. Your doctor will weigh results alongside your symptoms and medical history.
When would this test be repeated?
If your initial test is positive, your doctor may repeat it to monitor progression or response to treatment. If results are negative but you have concerning symptoms, further testing (like cultures) may be needed to investigate other causes of your condition.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy