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Candida antigen in serum/plasma (quantitative immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of Candida antigens in your blood, which can help detect fungal infections caused by the yeast *Candida*.

Quick summary

["Helps identify possible fungal infections early, even when blood cultures may not show growth."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
98394-0
Short code
CANDIDAMALDI
Synonyms
Candida Islt MS.MALDI-TOF
Category
chemistry
Sample
serum
Container
Sterile culture transport system appropriate for specimen type (e.g., blood culture bottles for blood, sterile screw-cap containers for tissue/fluid, swab transport system for mucosal/skin sites). Pure isolate on appropriate solid media (e.g., Sabouraud dextrose agar, CHROMagar Candida) submitted for MALDI-TOF analysis.
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
ms-maldi-tof
CPT
87140
SNOMED
40307004
Specimen volume
Specimen volume depends on source: blood cultures typically 8-10 mL per bottle (adult) or 1-3 mL (pediatric); tissue or fluid samples minimum 1 mL or 1 cm³. For isolate identification, a single colony or small loopful of purified yeast growth is sufficient for MALDI-TOF analysis.
Stability
Original clinical specimen: transport to laboratory within 2 hours at room temperature or per source-specific protocol; refrigerated (2-8°C) stability varies by specimen type. Pure yeast isolate on solid media: stable for MALDI-TOF analysis for up to 72 hours when stored at 2-8°C; prolonged storage on media or in glycerol stock at -70°C for archive.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
1–24 hours
Order
routine

What Is This Test Measuring?

The test detects specific antigens produced by *Candida* species, such as *Candida albicans*, in your blood. These antigens are fragments of the yeast that your immune system can recognize. The test is not specific to a single type of Candida but can indicate an active infection if present.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like fever, fatigue, or persistent mouth/throat sores, especially if you have a weakened immune system (e.g., from HIV, chemotherapy, or organ transplant). It’s also used in patients with persistent bloodstream infections or those with risk factors like diabetes or recent surgery.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then tested for Candida antigens using an immunoassay method, which detects the presence of these yeast fragments in your bloodstream.

What Do Results Mean?

A positive result suggests an active *Candida* infection, but it doesn’t confirm the exact type of yeast or location of the infection. A negative result means no detectable antigens were found in this sample, but repeated testing may be needed if symptoms persist.

Reference range

Not applicable (qualitative identification test). Result reported as 'Candida species identified' with species-level identification when achievable (e.g., C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, C. krusei, C. auris, etc.) or 'No Candida species isolated.'N/A

Specimen: serum

No special patient preparation required prior to sample collection. Sample collection (blood, tissue, body fluid, or other appropriate specimen) should be performed aseptically to avoid contamination. For suspected candidemia, collection prior to initiation of antifungal therapy is preferred when clinically feasible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Candida antigen test

Frequently asked questions

How often will I need this test?
This test is typically done once or twice if symptoms or risk factors suggest a fungal infection. Your provider may repeat it if you have ongoing symptoms or a history of recurrent infections.
What if my results are positive?
A positive result may lead to further testing, such as blood cultures or imaging, to pinpoint the infection’s location (e.g., lungs, bloodstream) and guide treatment with antifungal medications.
Can I prevent Candida infections?
Yes! Reducing risk factors like maintaining good hygiene, managing diabetes, avoiding excessive antibiotics, and keeping immune systems strong (e.g., through diet and exercise) can lower your risk. If you suspect an infection, follow your provider’s advice for treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy