Synthetic Cannabinoid Screening in Whole Blood
This test checks for synthetic cannabinoids, which are man-made psychoactive compounds sometimes used in illegal substances. These chemicals can mimic the effects of marijuana but are often more potent and unpredictable.
["This screening helps determine if synthetic cannabinoids have been present in your system recently."]
Key facts at a glance
- LOINC
- 73943-3
- Short code
- SYNTHCAN
- Synonyms
- Cannabinoids synthetic Bld Ql
- Category
- chemistry
- Sample
- whole-blood
- Container
- Gray-top sodium fluoride/potassium oxalate tube or EDTA lavender-top tube
- Units
- N/A
- Ref low
- 1
- Ref high
- 10
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
- CPT
- 80307
- SNOMED
- 440273004
- Specimen volume
- 5-10 mL whole blood
- Stability
- Refrigerated at 2-8°C: up to 7 days; Frozen at -20°C: up to 30 days; Room temperature: up to 24 hours
- Hemolysis max
- 100
- Lipemia max
- 100
- Icterus max
- 50
- TAT
- 48–168 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you’ve been exposed to synthetic cannabinoids, suspected of using them, or experiencing symptoms like altered mental state, severe anxiety, or physical distress that could be linked to these substances. It may also be part of a broader substance use evaluation.
What to Expect Before the Test
No special preparation is needed for this test. You’ll provide a small sample of whole blood drawn from a vein in your arm. The process is quick and typically done in a clinic or lab setting. If you’re pregnant, breastfeeding, or have a bleeding disorder, let your provider know before the test.
What the Test Results Mean
If synthetic cannabinoids are detected, it confirms recent use. The presence of these compounds does not necessarily indicate ongoing use, as they can be metabolized quickly. Results are used to guide further medical evaluation or treatment if needed.
What Happens Next
If positive results are found, your healthcare provider may recommend additional testing, such as follow-up bloodwork or a discussion about substance use and potential harm reduction strategies. They may also monitor for any health effects related to exposure.
Reference range
Negative (cutoff: typically 1-10 ng/mL depending on specific synthetic cannabinoid target)N/A
No special preparation required. Patients should be informed that synthetic cannabinoids may not be detected by standard cannabinoid immunoassays, and that several novel compounds may exist that are not included in testing panels.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Synthetic cannabinoids can cause severe health risks, including heart problems, seizures, and psychological distress. Early detection allows for prompt intervention, support, or medical treatment to mitigate risks. This test helps identify exposure for appropriate management and safety planning.
Short name
Synthetic Cannabinoid Screen (BLD)
Frequently asked questions
Will this test show if I’ve used synthetic cannabinoids in the past?
What symptoms might I experience if synthetic cannabinoids are in my system?
Can I drink alcohol or take other medications before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy