Carbamazepine (Serum/Free, Substance Concentration)
This test measures the amount of carbamazepine, a medication used to treat certain types of seizures or nerve-related pain, in your blood. It helps your healthcare provider check if the dose is working properly and if you’re experiencing side effects.
["Your carbamazepine levels help ensure safe and effective dosing for seizure control or pain management."]
Key facts at a glance
- LOINC
- 47097-1
- Short code
- CBZEPOX
- Synonyms
- Carbamazepine EP Free SerPl-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (serum) or plasma separator tube (PST, light green-top)
- Units
- N/A
- Ref low
- 4.2
- Ref high
- 12.6
- Critical range
- — – 37.8 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Liquid chromatography-tandem mass spectrometry (LC-MS/MS) or high-performance liquid chromatography (HPLC)
- CPT
- 80299
- SNOMED
- 395148005
- Specimen volume
- 1-2 mL of serum or plasma
- Stability
- Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days
- Hemolysis max
- 100
- Lipemia max
- 100
- Icterus max
- 50
- TAT
- 24–72 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you’re taking carbamazepine to manage conditions like epilepsy, bipolar disorder, or trigeminal neuralgia. It helps monitor whether the medication is at an appropriate level in your blood to prevent seizures or control symptoms without causing harmful side effects. This is especially important if you’re taking this medication long-term or if your dose has been recently adjusted.
How the Test Works
A blood sample is taken from a vein in your arm. The lab then uses a sensitive test (likely a high-performance liquid chromatography or immunoassay method) to measure the exact amount of carbamazepine in your serum or plasma. The result is reported as a concentration in micrograms per milliliter (mcg/mL) or another relevant unit.
What to Expect Before the Test
There are usually no special preparations needed. You may have some mild discomfort from the needle insertion, but this typically goes away quickly. If you’re on blood thinners or have a history of bleeding issues, let your doctor know before the test.
What to Expect After the Test
After the blood draw, you can return to your normal activities immediately. Apply gentle pressure to the site to stop any bleeding, and avoid rubbing or applying ice unless instructed. Most people don’t need to do anything special afterward.
Reference range
Therapeutic range: 1.0-3.0 mg/L (or 4.2-12.6 µmol/L) for the 10,11-epoxide metabolite when co-administered with carbamazepine; optimal therapeutic range not well established, interpret in clinical contextN/A
No special preparation required. Trough specimen should be collected immediately before the next scheduled dose for accurate steady-state monitoring.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Carbamazepine levels help determine if you’re at therapeutic levels (where the medication is effective but not toxic) or if adjustments are needed. Low levels may mean the medication isn’t working as intended, while high levels could indicate toxicity, such as dizziness, nausea, or rash. Your doctor will use these results alongside your symptoms and medical history to guide treatment.
Short name
Carbamazepine Level
Frequently asked questions
How Often Should I Get This Test?
What Does a Low or High Level Mean?
Can I Eat or Drink Before the Test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy