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Cardiolipin Antibody, IgG (Complement-Dependent Lysis)

Published: August 9, 2026Updated: August 15, 2026

This test measures the presence of antibodies against cardiolipin, a natural lipid found in cell membranes. These antibodies may be linked to certain autoimmune conditions.

Quick summary

This test helps evaluate potential autoimmune or inflammatory conditions, including lupus or other connective tissue disorders.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
42730-2
Short code
ACLAIGA
Synonyms
Cardiolipin IgA B2GP1 indep MoM Ser
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top tube without anticoagulant
Units
N/A
Ref low
0
Ref high
20
Critical range
— – 30 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–99 years
Method
Enzyme-linked immunosorbent assay (ELISA) for detection of IgA anticardiolipin antibodies independent of beta-2 glycoprotein 1 (β2GP1) cofactor
CPT
86147
SNOMED
31346002
Specimen volume
1.0 mL serum minimum; 0.5 mL acceptable for repeat testing
Stability
Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 6 months. Avoid repeated freeze-thaw cycles.
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms suggestive of autoimmune diseases, such as joint pain, unexplained rashes, or fatigue. It may also be used to monitor conditions like systemic lupus erythematosus (SLE) or antiphospholipid syndrome.

What Does a Positive Result Mean?

A positive result indicates the presence of cardiolipin antibodies, which can be associated with autoimmune conditions. However, not all positive results mean you have an active disease; some people may have these antibodies without symptoms.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The sample is then analyzed in a lab to detect the presence of cardiolipin antibodies using a specialized immunoassay method.

What Are Common Symptoms Linked to This Test?

Symptoms that may prompt this test include persistent joint pain, skin rashes (like butterfly-shaped rash on the face), fever, fatigue, or blood clotting issues. These symptoms can vary widely and may not directly relate to the antibody test itself.

Reference range

Negative: <20 MPL (IgA phospholipid units); Equivocal: 20-30 MPL; Positive: >30 MPL. Results expressed as multiples of the median (MoM).N/A

Specimen: serum

No fasting required. Patients should be well-hydrated. Avoid recent heparin therapy if possible as it may interfere with phospholipid-based assays.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Cardiolipin antibodies are often investigated in patients with autoimmune diseases, particularly those involving the blood vessels or connective tissues. While not definitive, their presence can support a diagnosis of conditions like antiphospholipid syndrome or lupus. Further testing and clinical correlation are needed to determine the exact cause of symptoms.

Short name

IgG Cardiolipin Antibody (CDLA)

Frequently asked questions

What does a positive cardiolipin antibody test mean for my health?
A positive test means you have antibodies against cardiolipin, which may increase the risk of certain autoimmune conditions. Your healthcare provider will discuss this with you and may recommend additional tests or monitoring to understand your health better.
Will I need more tests if this result is positive?
Yes, additional tests may be needed to evaluate your symptoms and overall health. These could include other antibody tests, blood clotting studies, or evaluations for autoimmune diseases like lupus or antiphospholipid syndrome.
Can lifestyle changes help if my cardiolipin antibody test is positive?
While lifestyle changes like managing stress, maintaining a balanced diet, and staying physically active can support overall health, they do not directly address the presence of cardiolipin antibodies. Your healthcare provider will guide you on managing any potential underlying conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy