Cardiolipin Antibody (IgG) - Serum
This test measures the presence of antibodies against cardiolipin, a component found in cell membranes. These antibodies may be linked to certain autoimmune conditions.
["Cardiolipin antibodies can help identify possible autoimmune disorders or conditions like lupus or other connective tissue diseases."]
Key facts at a glance
- LOINC
- 110043-7
- Short code
- CARDIOLIPA
- Synonyms
- Cardiolipin IgA Msmt Ser
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or red-top tube
- Units
- N/A
- Ref low
- 0
- Ref high
- 10
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Enzyme-Linked Immunosorbent Assay (ELISA)
- CPT
- 86147
- SNOMED
- 4445-8
- Specimen volume
- 1-2 mL serum (minimum 0.5 mL)
- Stability
- Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or lower): 6 months. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 100
- Lipemia max
- 100
- Icterus max
- 50
- TAT
- 24–72 hours
- Order
- routine
What This Test Measures
The test detects IgG antibodies that target cardiolipin, a phospholipid found in cell membranes. These antibodies are sometimes associated with autoimmune responses, though their exact role is still being studied.
Why It’s Ordered
Your healthcare provider may order this test if you have symptoms suggestive of autoimmune conditions, such as joint pain, unexplained fatigue, or other signs of lupus or other connective tissue diseases. It may also be used as part of a broader evaluation for unexplained clotting issues or other inflammatory conditions.
Common Conditions Linked to Positive Results
Positive results may indicate an autoimmune response, though they are not definitive for a diagnosis. Conditions that might be associated include systemic lupus erythematosus (SLE), antiphospholipid syndrome, or other autoimmune disorders. False positives can occur, so results should be interpreted in the context of your overall health and symptoms.
What to Expect Before the Test
No special preparation is needed for this test. You may have a small needle inserted into a vein in your arm to draw a blood sample. The process is quick and typically painless. If you’re on blood thinners or have a history of bleeding issues, let your provider know before the test.
Reference range
Negative: <10 MPL units/mL (or <10 U/mL depending on assay); Positive: ≥10 MPL units/mL. Low positive: 10-40 MPL units/mL; High positive: >40 MPL units/mL. Reference ranges vary by laboratory and assay manufacturer.N/A
No fasting required. Patient should be well-hydrated. Avoid testing during acute illness or infection, as transient elevations may occur. If testing for antiphospholipid syndrome, confirm positive results with repeat testing after at least 12 weeks.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
IgG Cardiolipin Antibodies
Frequently asked questions
How long will it take to get my results?
Can I fast before this test?
What does a positive result mean for my health?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy