Skip to content

Cardiolipin Antibody, Total (Plasma/Serum)

Published: August 9, 2026Updated: August 15, 2026

This test measures the presence of antibodies against cardiolipin, a natural lipid found in cell membranes, often used to evaluate for lupus anticoagulant or antiphospholipid syndrome.

Quick summary

["This test helps assess certain autoimmune conditions linked to blood clotting issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
8063-0
Short code
CLIGA
Synonyms
Cardiolipin IgA SerPl-aCnc
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top vacutainer tube
Units
N/A
Ref low
0
Ref high
9
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Enzyme-Linked Immunosorbent Assay (ELISA)
CPT
86147
SNOMED
44241-3
Specimen volume
1.0 mL serum or plasma
Stability
Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C): 30 days. Avoid repeated freeze-thaw cycles.
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like unexplained blood clots, recurrent miscarriages, or other signs of autoimmune disorders. It may also be used to monitor conditions like lupus or antiphospholipid syndrome.

What Does the Test Measure?

The test detects antibodies that target cardiolipin, a component found in cell membranes. These antibodies can be part of a broader pattern of antiphospholipid antibodies, which may affect blood clotting.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The sample is then processed to measure antibody levels against cardiolipin using an immunoassay method.

What Are Possible Results?

Results are qualitative (positive or negative) and may be part of a broader panel that includes other antiphospholipid antibodies. Elevated levels may suggest an autoimmune condition.

Reference range

Negative: <10 U/mL; Equivocal: 10-14 U/mL; Positive: >14 U/mLN/A

Specimen: serum

No special patient preparation required. Fasting is not necessary.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cardiolipin Antibodies

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of cardiolipin antibodies, which may be associated with autoimmune disorders affecting blood clotting. Further testing and evaluation by your healthcare provider are needed to determine the cause and next steps.
How often should I get this test?
Your healthcare provider will determine the frequency of testing based on your symptoms, medical history, and treatment needs. Follow their guidance for follow-up testing.
Can lifestyle changes affect this test?
While lifestyle factors like diet or stress may influence overall health, they typically do not directly affect antibody levels measured in this test. Always discuss any concerns with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy