Cardiolipin Antibody (IgG) - Serum
This test measures the presence of antibodies against cardiolipin, a fatty substance found in cell membranes. These antibodies may be linked to certain autoimmune conditions.
["This test helps assess for potential autoimmune disorders like lupus or other connective tissue diseases."]
Key facts at a glance
- LOINC
- 42732-8
- Short code
- CARDIOLG
- Synonyms
- Cardiolipin IgG B2GP1 indep MoM Ser
- Category
- chemistry
- Sample
- serum
- Container
- Serum Separator Tube (SST) - Red-top or Gold-top (Tiger-top) Vacutainer tube
- Units
- N/A
- Ref low
- 0
- Ref high
- 10
- Critical range
- — – 40 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Enzyme-Linked Immunosorbent Assay (ELISA) - Beta-2 Glycoprotein 1 Independent
- CPT
- 86147
- SNOMED
- 1153410004
- Specimen volume
- 1.0 mL serum (minimum 0.5 mL)
- Stability
- Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 6 months. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 100
- Lipemia max
- 200
- Icterus max
- 25
- TAT
- 24–72 hours
- Order
- routine
What Is Cardiolipin Antibody Testing For?
Cardiolipin antibodies are often checked in people suspected of having autoimmune diseases, such as systemic lupus erythematosus (SLE) or antiphospholipid syndrome. These conditions can cause blood clots, joint pain, or other symptoms. Your doctor may recommend this test if you have unexplained symptoms like fatigue, rashes, or blood clots.
Why Might You Need This Test?
Your healthcare provider might order this test if you have symptoms that could be linked to autoimmune disorders, such as persistent fatigue, unexplained joint pain, skin rashes, or a history of blood clots. It may also be used as part of a broader evaluation for conditions like lupus or other connective tissue diseases.
How Is This Test Performed?
A small blood sample is drawn from a vein in your arm. The blood is then sent to a lab for testing using an immunoassay method to detect cardiolipin antibodies. The results are compared to known reference ranges to determine if antibodies are present.
What Do the Results Mean?
Positive results for cardiolipin antibodies may suggest an increased risk of autoimmune conditions. However, they are not definitive on their own. Your doctor will consider your symptoms, medical history, and other test results to make a diagnosis.
Reference range
Negative: <10 GPL-U/mL; Indeterminate: 10-40 GPL-U/mL; Positive: >40 GPL-U/mL. Results expressed as Multiple of the Median (MoM) relative to laboratory reference standard.N/A
No fasting required. Avoid heparin therapy prior to collection if possible, as heparin may interfere with cardiolipin antibody detection. Inform provider of any anticoagulant medications.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Cardiolipin Antibodies and Autoimmune Conditions
Short name
IgG Cardiolipin Antibodies
Frequently asked questions
What are the normal ranges for this test?
How often should I get this test?
Can cardiolipin antibodies be treated?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy