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Cardiolipin Antibody (IgG) - Serum

Published: August 9, 2026Updated: August 15, 2026

This test measures the presence of antibodies to cardiolipin, a lipid found in cell membranes, often used to help evaluate conditions like lupus or other autoimmune disorders.

Quick summary

["This test helps assess potential autoimmune activity linked to certain blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
24385-7
Short code
CARDIOLG
Synonyms
Cardiolipin IgG Ser Ql IA
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red top tube
Units
N/A
Ref low
0
Ref high
10
Fasting
false
Population
adult
Sex
all
Age range
≥ 18 years
Method
Immunoassay (Enzyme-linked immunosorbent assay or chemiluminescent immunoassay)
CPT
86147
SNOMED
50726007
Specimen volume
1 mL serum (minimum 0.5 mL)
Stability
Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms or risk factors for autoimmune diseases, such as unexplained joint pain, rash, or fatigue. It may also be used alongside other tests to diagnose conditions like lupus or antiphospholipid syndrome.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein in your arm to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Test Results Mean

Results are qualitative (positive or negative) and not used alone to diagnose conditions. They’re often part of a broader evaluation, including other blood tests and clinical findings.

Common Conditions Linked to This Test

Positive results may suggest an increased risk of autoimmune disorders, but they don’t confirm a diagnosis. Your provider will consider the full clinical picture.

Reference range

Negative: <10 GPL U/mL; Equivocal: 10-40 GPL U/mL; Positive: >40 GPL U/mLN/A

Specimen: serum

No fasting required. No special patient preparation necessary. Avoid hemolyzed or lipemic specimens as they may interfere with assay performance.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Cardiolipin Antibody

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of cardiolipin antibodies, which may raise suspicion for autoimmune activity. It’s not definitive on its own and often requires further testing and clinical correlation.
Can diet or supplements affect this test?
Dietary changes or supplements typically don’t interfere with this test, but if you’re on medications (e.g., blood thinners), inform your provider before testing.
How often should I get this test?
Frequency depends on your symptoms and medical needs. Your provider will determine how often to repeat this test based on your individual care plan.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy