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Genetic Mutation Analysis of Blood (Whole Blood) for Cancer-Related Suspicion (CATCH-22 Screening)

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific genetic mutations linked to certain cancers or hereditary conditions, using a sample of your blood. It may be part of a broader screening process.

Quick summary

["This test helps identify inherited genetic risks that could increase your cancer risk over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
36912-4
Short code
CATCH22
Synonyms
CATCH22 gene Mut Tested Bld/T
Category
chemistry
Sample
whole-blood
Container
EDTA (purple-top) tube for whole blood; sterile container for tissue specimens
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
molgen
CPT
81408
SNOMED
444950007
Specimen volume
3-5 mL whole blood in EDTA tube; minimum 2 mL for pediatric samples; 5-10 mg tissue for biopsy specimens
Stability
Whole blood: stable for 7 days at 2-8°C; ambient temperature for 24 hours. Tissue: stable in DNA preservative or frozen at -20°C for long-term storage. Extracted DNA stable for years at -20°C or -80°C
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
168–720 hours
Order
routine

What This Test Measures

The test detects mutations in genes associated with cancer development, such as those involved in DNA repair or cell growth regulation. These mutations may be inherited or acquired. Results focus on high-risk genes that could influence future health decisions.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of certain cancers, or if you’re at higher risk due to age, ethnicity, or other factors. It’s not a routine screening but may be part of a personalized cancer prevention plan.

Sample Collection and Process

A blood sample is drawn from your arm, similar to other blood tests. The sample is then analyzed in a lab to identify specific genetic mutations using advanced genetic testing techniques.

What to Expect Before the Test

No special preparation is needed, but inform your provider about any medications, supplements, or recent illnesses that could affect results. Avoid strenuous activity 24 hours before the test.

Reference range

No disease-causing mutations or pathogenic deletions detected in the CATCH22/22q11.2 deletion syndrome critical region (TBX1, COMT, and associated genes). Reportable results: positive (pathogenic variant detected), negative (no pathogenic variant detected), or variant of uncertain significance (VUS)N/A

Specimen: whole-blood

No special fasting required. Genetic counseling is recommended before and after testing. Informed consent may be required per institutional policy. A detailed family history and clinical phenotype description should accompany the test request for accurate interpretation

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results may indicate an increased risk for certain cancers or hereditary conditions. These findings can guide discussions about genetic counseling, risk-reducing strategies, or closer monitoring. Negative results suggest no detected mutations in the tested genes, but they do not rule out other genetic risks.

Short name

CATCH-22 Genetic Mutation Test (Blood)

Frequently asked questions

Will this test show all possible genetic mutations?
No, this test only checks for specific mutations in a limited set of genes associated with high-risk cancers. It’s not a comprehensive genetic test and may miss other genetic variations.
What does a positive result mean?
A positive result means the test identified mutations in the genes tested. This could mean you’re at higher genetic risk for certain cancers, but it doesn’t confirm cancer right away. You’ll need to discuss next steps with your healthcare provider.
Can I stop taking medications before this test?
Generally, you don’t need to stop medications unless your provider advises otherwise. Some medications or supplements may affect lab results, so always check with your healthcare team first.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy