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Cerebrospinal fluid (CSF) DNA probe analysis for quantitative measurement of specific genetic sequences

Published: August 9, 2026Updated: August 16, 2026

This test checks for certain DNA sequences in your cerebrospinal fluid (the fluid around your brain and spinal cord) using a genetic probe. It may help evaluate conditions affecting the central nervous system, such as genetic disorders or certain infections.

Quick summary

["This test helps identify genetic markers in your brain’s fluid that could relate to neurological or genetic conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95764-7
Short code
CAURISU
Synonyms
C auris DNA Ur Ql NAA+n-prb
Category
chemistry
Sample
urine
Container
Sterile, leak-proof urine collection container (preferably a primary container without preservatives) or a urine transport tube suitable for molecular testing
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
non-probe-amp-tar
CPT
87798
SNOMED
122450008
Specimen volume
10-50 mL of urine; minimum 1-2 mL required for molecular testing
Stability
Refrigerated (2-8°C): up to 7 days; Frozen (-20°C or lower): up to 30 days. Transport to laboratory as soon as possible. If delayed, refrigerate specimen.
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
24–72 hours
Order
routine

What Does This Test Measure?

The test detects and quantifies specific DNA fragments in your cerebrospinal fluid. These sequences may be linked to inherited genetic conditions, infections, or other neurological abnormalities. The probe binds to these sequences, allowing for precise measurement of their presence and concentration.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have symptoms like unexplained headaches, seizures, movement disorders, or if there’s a family history of genetic neurological diseases. It can also be used to monitor certain genetic conditions or guide treatment decisions.

Sample Collection and Preparation

A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then processed in a lab to extract and analyze the DNA sequences using the genetic probe method.

What to Expect Before the Test

You’ll typically be asked to fast for a few hours before the procedure, though this may vary. Wear comfortable clothing, and inform your doctor about any medications you’re taking, as some may affect the test results or procedure.

Reference range

Negative (Not Detected)N/A

Specimen: urine

No special patient preparation required. Standard urine collection techniques should be followed. For catheterized patients, specimen should be collected from the sampling port using aseptic technique.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF DNA Testing

Frequently asked questions

How is the DNA probe used in this test?
The probe is a specialized tool designed to bind only to specific DNA sequences in your CSF. When the fluid is analyzed, the probe detects and quantifies these sequences, helping identify whether they are present at abnormal levels that may indicate a condition.
What conditions might this test detect?
This test may detect genetic markers associated with conditions like hereditary ataxias, certain types of dementia, or genetic disorders affecting nerve function. It can also help diagnose infections or inflammatory processes in the central nervous system.
Do I need to prepare for this test in any special way?
Yes, you may need to fast for a few hours before the procedure, avoid strenuous activity, and inform your doctor about any medications you’re taking to ensure safe collection of the sample.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy