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Anti-Borrelia burgdorferi IgG antibody (serum/plasma)

Published: August 9, 2026Updated: August 15, 2026

This test measures the presence of antibodies against *Borrelia burgdorferi*, the bacterium responsible for Lyme disease. Antibodies develop after infection and can help confirm past exposure.

Quick summary

["This test helps diagnose or rule out Lyme disease by detecting immune system response to the Lyme bacterium."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
32644-7
Short code
COXPH1
Synonyms
C burnet Ph1 IgG Ser Ql
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top clot tube
Units
N/A
Ref low
0
Ref high
1
Critical range
— – 799 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Immunofluorescence assay (IFA) detecting phase 1-specific IgG antibodies
CPT
86638
SNOMED
122440007
Specimen volume
1-2 mL of serum
Stability
Stable for 7 days at 2-8°C; for extended storage, freeze at -20°C or below
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–168 hours
Order
routine

This test measures a specific substance, marker, or cell level in your body, and the results help your healthcare provider understand how well certain organs or systems are working. Your provider will explain exactly what is being measured and what your numbers mean for your overall health and ongoing care.

The test looks for IgG antibodies specific to *Borrelia burgdorferi*, a bacterium transmitted through tick bites. These antibodies indicate an immune response, which may suggest past infection. IgG antibodies typically appear weeks to months after exposure and can persist long-term.

Your doctor may order this test if you have symptoms that need evaluation, if you have a condition that requires regular monitoring, or as part of a routine checkup. The results can help confirm a diagnosis, track how well a treatment is working, or screen for possible health concerns before symptoms appear.

Your healthcare provider may order this test if you have symptoms like joint pain, fatigue, or a rash (erythema migrans) that could be linked to Lyme disease. It may also be used in cases of recurrent symptoms or after a tick bite, especially in high-risk areas.

For this test, a small sample of blood is typically drawn from a vein in your arm by a trained phlebotomist, or it may be collected with a simple finger stick. Little to no preparation is needed, but you should tell your provider about any medications, vitamins, or supplements you take, since some can affect your results.

A blood sample is drawn from a vein in your arm. The blood is processed to separate serum or plasma, which is then tested for IgG antibodies using an immunoassay method. This test does not require fasting.

Before the test, your healthcare provider will review your medical history and explain why the test is being done. You can usually eat and drink normally unless your provider gives you other instructions, and you should keep taking your regular medications unless told otherwise. The appointment typically takes only a few minutes, and you can let the staff know if you feel uneasy about needles.

No special preparation is needed. Wear comfortable clothing and bring any medications you’re currently taking, as some may affect test results.

Reference range

Negative: <1:200; Positive: ≥1:200. Phase 1 IgG titer ≥1:800 is considered diagnostic for chronic Q fever infectionN/A

Specimen: serum

No special patient preparation required. Acute and convalescent serum samples (2-4 weeks apart) are recommended for accurate interpretation

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results suggest past infection with *Borrelia burgdorferi* and may indicate Lyme disease. However, false positives can occur, especially with other infections or autoimmune conditions. Negative results do not rule out Lyme disease if symptoms persist or if testing was done too early after exposure. Follow-up testing or additional evaluation may be needed.

Short name

Borrelia IgG Antibody

Frequently asked questions

When might I get false-positive or false-negative results?
False positives can happen if you have other infections, autoimmune conditions, or if the test was done too soon after a tick bite. False negatives may occur if testing was done too early (before antibody development) or if the test was not repeated after symptoms develop.
Can this test detect Lyme disease in its early stages?
No, this test primarily detects IgG antibodies, which develop weeks to months after infection. Early-stage Lyme disease may require other tests (like ELISA or Western blot) or clinical correlation with symptoms.
Does this test require fasting?
No, fasting is not required for this blood test. You may eat and drink normally before your appointment, including your usual meals and water. If your provider orders additional tests at the same visit that do require fasting, you will receive specific instructions ahead of time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy