Cryoglobulin (IgG/IgM) in Serum or Plasma
This test measures the presence of abnormal proteins called cryoglobulins in your blood, which can thicken and form clumps when the body is cool. These proteins may be linked to certain autoimmune conditions.
["Cryoglobulins can cause symptoms like swelling, fatigue, or skin changes when exposed to cold temperatures."]
Key facts at a glance
- LOINC
- 49184-5
- Short code
- COX2IGA
- Synonyms
- C burnet Ph2 IgA Titr Fld
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST), red-top tube, or sterile body fluid collection container
- Units
- N/A
- Ref low
- 0
- Ref high
- 1
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- immunofluorescence assay (IFA)
- CPT
- 86638
- SNOMED
- 313327003
- Specimen volume
- 1-2 mL of serum or body fluid
- Stability
- Serum stable at 2-8°C for 7 days; frozen at -20°C or below for up to 30 days. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 100
- Lipemia max
- 100
- Icterus max
- 50
- TAT
- 48–168 hours
- Order
- routine
What Is a Cryoglobulin Test Used For?
Doctors may order this test to diagnose or monitor conditions such as cryoglobulinemia, a rare blood disorder where these proteins clump together. It can also help identify autoimmune diseases like hepatitis C, where cryoglobulins are often found.
How Is the Sample Collected?
A small amount of blood is drawn from a vein in your arm. The blood is placed in a tube and sent to the lab for testing. If you’re taking blood thinners, let your doctor know before the test.
What Are Possible Results?
Results may show elevated levels of cryoglobulins, indicating potential clumping in cold conditions. A normal result means no abnormal proteins were detected in this sample.
What Does It Mean If Results Are Abnormal?
High levels of cryoglobulins may suggest conditions like autoimmune diseases, infections (e.g., hepatitis C), or other blood disorders. Your doctor will discuss findings with you based on your symptoms and medical history.
Reference range
Negative: <1:16; Positive: ≥1:16. Titer results reported as the reciprocal of the highest dilution yielding detectable antibody.N/A
No special preparation or fasting required. Patient should be well-hydrated prior to venipuncture.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Cryoglobulins can cause circulation problems, skin rashes, joint pain, or fatigue. Early detection helps manage symptoms and prevent complications like nerve damage or organ damage in severe cases.
Short name
Cryoglobulin Level
Frequently asked questions
Why might my doctor recommend this test?
What should I do if I have abnormal results?
Can diet or lifestyle changes affect cryoglobulin levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy