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Borrelia burgdorferi IgG Antibody, Serum (Qualitative Immunoassay)

Published: August 9, 2026Updated: August 15, 2026

This test checks for antibodies to *Borrelia burgdorferi*, the bacterium responsible for Lyme disease, using a blood sample from your serum.

Quick summary

["Detects past or current Lyme disease exposure through antibody presence."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
9711-3
Short code
COX2M
Synonyms
C burnet Ph2 IgM Titr Ser
Category
chemistry
Sample
serum
Container
Serum separator tube (SST, tiger-top or gold-top, 5 mL) or red-top tube for serum collection
Units
N/A
Ref low
0
Ref high
1
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Immunofluorescence Assay (IFA)
CPT
86638
SNOMED
1083351000119104
Specimen volume
1–2 mL serum (minimum 0.5 mL)
Stability
Serum stable at 2–8°C for 7 days; for extended storage, freeze at -20°C or below for up to 30 days. Avoid repeated freeze-thaw cycles.
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
48–168 hours
Order
routine

What This Test Measures

The test identifies antibodies produced by your immune system in response to exposure to *Borrelia burgdorferi*. Antibodies are proteins your body makes to fight infections. If you’ve been exposed to the bacterium, these antibodies may be detected in your blood. This test is qualitative, meaning it only tells you if antibodies are present or not, rather than measuring their exact amount.

How the Test Works

Your blood serum is tested using an immunoassay method, which detects specific antibodies against *Borrelia burgdorferi*. This method is sensitive and designed to identify even low levels of these antibodies, helping to confirm past infection or exposure.

When You Might Need This Test

A healthcare provider may recommend this test if you have symptoms of Lyme disease (such as fever, rash, or joint pain) after being bitten by a tick in an endemic area, or if you’ve lived in or traveled to a region where Lyme disease is common. It can also be used for screening or monitoring in certain clinical settings.

Limitations and Considerations

This test cannot diagnose Lyme disease directly—it only indicates whether your body has produced antibodies to the bacterium. False positives can occur, especially in people with other infections or autoimmune conditions. A positive result should be followed up with clinical evaluation and possibly additional testing, such as a Western blot, for confirmation.

Reference range

Negative: <1:16; Equivocal: 1:16–1:32; Positive: ≥1:64. Phase 2 IgM antibodies appear in early acute Q fever infection, typically detectable 2–3 weeks after symptom onset.N/A

Specimen: serum

No special preparation required. Avoid collecting during the acute febrile phase only; ideally collect both acute (within first week) and convalescent (2–4 weeks later) specimens for seroconversion documentation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Borrelia IgG Antibody (Serum)

Frequently asked questions

Why was this test ordered?
Your healthcare provider may have ordered this test to assess for past or current Lyme disease exposure, particularly if you’ve had symptoms suggestive of Lyme disease or a tick bite in a high-risk area. It can help guide further diagnostic steps or treatment decisions.
What does a positive result mean?
A positive result suggests your body has likely been exposed to *Borrelia burgdorferi* at some point, meaning you may have had Lyme disease or been exposed to the bacterium. However, this does not confirm a current infection. Follow-up testing and clinical evaluation are needed to determine if treatment is necessary.
Can this test be used to confirm Lyme disease?
No, this test alone cannot confirm Lyme disease. It is typically used as part of a broader diagnostic approach, including clinical assessment and possibly additional tests like a Western blot, to confirm infection.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy