Borrelia burgdorferi IgG Antibody, Serum (Qualitative Immunoassay)
This test checks for antibodies to *Borrelia burgdorferi*, the bacterium responsible for Lyme disease, using a blood sample from your serum.
["Detects past or current Lyme disease exposure through antibody presence."]
Key facts at a glance
- LOINC
- 9711-3
- Short code
- COX2M
- Synonyms
- C burnet Ph2 IgM Titr Ser
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST, tiger-top or gold-top, 5 mL) or red-top tube for serum collection
- Units
- N/A
- Ref low
- 0
- Ref high
- 1
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Immunofluorescence Assay (IFA)
- CPT
- 86638
- SNOMED
- 1083351000119104
- Specimen volume
- 1–2 mL serum (minimum 0.5 mL)
- Stability
- Serum stable at 2–8°C for 7 days; for extended storage, freeze at -20°C or below for up to 30 days. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 100
- Lipemia max
- 100
- Icterus max
- 50
- TAT
- 48–168 hours
- Order
- routine
What This Test Measures
The test identifies antibodies produced by your immune system in response to exposure to *Borrelia burgdorferi*. Antibodies are proteins your body makes to fight infections. If you’ve been exposed to the bacterium, these antibodies may be detected in your blood. This test is qualitative, meaning it only tells you if antibodies are present or not, rather than measuring their exact amount.
How the Test Works
Your blood serum is tested using an immunoassay method, which detects specific antibodies against *Borrelia burgdorferi*. This method is sensitive and designed to identify even low levels of these antibodies, helping to confirm past infection or exposure.
When You Might Need This Test
A healthcare provider may recommend this test if you have symptoms of Lyme disease (such as fever, rash, or joint pain) after being bitten by a tick in an endemic area, or if you’ve lived in or traveled to a region where Lyme disease is common. It can also be used for screening or monitoring in certain clinical settings.
Limitations and Considerations
This test cannot diagnose Lyme disease directly—it only indicates whether your body has produced antibodies to the bacterium. False positives can occur, especially in people with other infections or autoimmune conditions. A positive result should be followed up with clinical evaluation and possibly additional testing, such as a Western blot, for confirmation.
Reference range
Negative: <1:16; Equivocal: 1:16–1:32; Positive: ≥1:64. Phase 2 IgM antibodies appear in early acute Q fever infection, typically detectable 2–3 weeks after symptom onset.N/A
No special preparation required. Avoid collecting during the acute febrile phase only; ideally collect both acute (within first week) and convalescent (2–4 weeks later) specimens for seroconversion documentation.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Borrelia IgG Antibody (Serum)
Frequently asked questions
Why was this test ordered?
What does a positive result mean?
Can this test be used to confirm Lyme disease?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy