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Placental growth factor (PLGF) concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of placental growth factor (PLGF) in your blood. PLGF is a protein involved in blood vessel formation and may be important during pregnancy.

Quick summary

["PLGF helps assess blood flow and vascular health, especially in pregnancy."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
82576-0
Short code
cCP IgA SerPl-aCnc
Synonyms
cCP IgA SerPl-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Placental Growth Factor (PLGF)?

PLGF is a protein produced by the placenta that plays a role in regulating blood vessel growth. It belongs to a group of proteins called vascular endothelial growth factors (VEGFs). While PLGF is primarily studied in pregnancy, its presence in blood can also reflect broader vascular health.

Why Might You Need This Test?

PLGF testing may be used in pregnancy to monitor conditions affecting blood flow, such as preeclampsia or placental insufficiency. It can also be part of broader evaluations for vascular disorders outside pregnancy.

When Is PLGF Tested?

This test is often ordered during pregnancy to assess placental function or to investigate symptoms like high blood pressure, protein in urine, or reduced fetal movement. Outside pregnancy, it may be considered for vascular-related concerns.

What Does a Result Mean?

Results are not typically interpreted alone but in the context of other tests and clinical findings. Abnormal levels may signal placental or vascular issues, but interpretation depends on the clinical scenario.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

PLGF

Frequently asked questions

What are the normal reference ranges for PLGF?
Reference ranges for PLGF vary by lab and pregnancy stage. Your healthcare provider will discuss your specific result in relation to your medical history and test context.
How is PLGF tested?
PLGF is measured using an immunoassay (a blood test that detects specific proteins) from serum or plasma. A blood sample is drawn, and the lab analyzes the protein concentration.
Can PLGF test results change over time?
Yes, PLGF levels can fluctuate, especially during pregnancy. Your results may be compared to baseline values or other related tests to guide decisions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy