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Serum Creatinine (with optional 24-hour urine collection for creatinine clearance calculation)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or urine. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function and identify potential kidney problems early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23687-7
Short code
CCV-AB
Synonyms
CCV Ab Ser Ql IF
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top vacutainer tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Immunofluorescence Assay (IFA)
CPT
86658
SNOMED
31153008
Specimen volume
1-2 mL of serum
Stability
Stable for 7 days at 2-8°C; for extended storage, freeze at -20°C or below for up to 6 months; avoid repeated freeze-thaw cycles
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

Why This Test Is Done

Doctors order a creatinine test to monitor kidney health, especially if you have symptoms like swelling, fatigue, or changes in urine output. It may also be used before surgeries, during pregnancy, or if you have conditions like diabetes or high blood pressure that put your kidneys at risk.

What to Expect Before the Test

No special preparation is needed for a blood test. For a 24-hour urine test, collect all urine over 24 hours (starting after morning pee) in a container. Drink normal fluids unless instructed otherwise.

What Happens During the Test

A blood sample is taken from your arm, or a urine sample is collected. The lab analyzes the sample using an automated method to measure creatinine levels.

What the Results Mean

Results are compared to a general reference range, but exact values depend on lab methods. High levels may suggest kidney problems, while low levels could indicate muscle loss or liver disease.

Reference range

Negative: No antibodies detected; Positive: Antibodies detected at a titer of 1:10 or greaterN/A

Specimen: serum

No special patient preparation required. Fasting is not necessary for this serological test

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine levels are a key indicator of kidney function. Elevated levels often signal impaired kidney filtration, which can lead to serious conditions like chronic kidney disease (CKD). It’s also used to calculate creatinine clearance—a measure of kidney function when combined with urine tests. Early detection helps manage conditions like diabetes or hypertension and guides treatment decisions.

Short name

Creatinine Level

Frequently asked questions

What causes creatinine levels to be high?
High creatinine levels can result from kidney disease, dehydration, severe muscle breakdown, or conditions that reduce blood flow to the kidneys (e.g., heart failure). Chronic kidney disease, diabetes, or high blood pressure are common long-term causes.
What causes creatinine levels to be low?
Low creatinine levels may indicate muscle atrophy (e.g., from malnutrition or aging), liver disease, or conditions that reduce muscle mass. Rarely, it could signal overhydration or errors in lab testing.
Can diet affect creatinine levels?
Dietary protein intake can influence creatinine levels, but the effect is usually minor unless you have extreme dietary changes (e.g., very low or very high protein diets). Hydration status is more directly tied to creatinine concentration in urine.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy