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Cytology: Cell Count in Fluid (Confirmed)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of cells present in a body fluid sample, such as cerebrospinal fluid (CSF), to help diagnose conditions affecting cell populations.

Quick summary

["A cell count helps identify abnormal cell presence that may signal infections, inflammation, or other health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40861-7
Short code
CD103
Synonyms
CD103 Cells NFr Tiss
Category
chemistry
Sample
serum
Container
Sterile tissue container with 10% neutral buffered formalin (for IHC) or RPMI transport medium (for flow cytometry); sterile saline acceptable for short-term transport
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Immunohistochemistry (IHC) or Flow Cytometry with CD103-specific monoclonal antibody staining
CPT
88342 (immunohistochemistry, first antibody stain) or 88184 (flow cytometry, cell surface marker, technical component)
SNOMED
250635005 (CD103 antigen) / 387713003 (immunohistochemistry procedure)
Specimen volume
Tissue biopsy specimen of adequate size (minimum 0.5 cm); for flow cytometry, minimum 1-2 cm³ fresh tissue in appropriate transport medium
Stability
Formalin-fixed tissue: stable indefinitely at room temperature; Fresh tissue for flow cytometry: stable for 24 hours at 2-8°C in transport medium; do not freeze fresh specimens intended for flow cytometry
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
48–168 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you have symptoms like headaches, neck stiffness, or neurological issues that could indicate conditions such as meningitis, brain tumors, or other fluid-related disorders. It’s also used to monitor treatment progress or check for hidden infections.

What to Expect Before the Test

No special preparation is needed unless your doctor specifies. If the fluid sample comes from a spinal tap (lumbar puncture), you may need to fast or avoid certain medications. Follow your healthcare provider’s instructions carefully.

What Happens During the Test

The test involves collecting fluid (e.g., CSF) through a needle inserted into your spine or another body cavity. The fluid is then sent to a lab, where trained professionals count and examine the cells under a microscope.

What the Results Mean

Results show the total cell count, which may include white blood cells (indicating infection or inflammation), red blood cells (suggesting bleeding), or other cell types. Abnormal counts can point to specific conditions, but interpretation depends on clinical context.

Reference range

Interpretation provided in report; CD103 expression is qualitative (positive/negative) and reported as percentage of cells expressing CD103 marker within the tissue specimenN/A

Specimen: serum

No fasting required. Specimen collection typically occurs during biopsy or surgical procedure. Patient should follow standard pre-procedural instructions provided by their healthcare provider. Inform physician of any anticoagulant or antiplatelet medication use prior to tissue sampling

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cell Count in Body Fluid (Confirmed)

Frequently asked questions

How does a high cell count in fluid affect my health?
A high cell count may signal infections (e.g., bacterial or viral meningitis), autoimmune diseases, or tumors. A low count could indicate normal fluid balance or certain neurological disorders. Always discuss results with your doctor, as they’ll consider your symptoms and medical history.
What if my test results are abnormal?
If results are abnormal, your doctor may recommend further testing (e.g., cultures, imaging) or adjustments to treatment. Follow-up visits will help clarify the cause and guide next steps.
Can I eat or drink before this test?
For spinal fluid tests, avoid heavy meals or fluids 6–8 hours before the procedure. If fluid is collected from another site (e.g., joint aspiration), follow your doctor’s specific instructions, as they may require fasting or medication adjustments.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy