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Quantitative Immunoassay for CD107a (LAMP-1) in Whole Blood Cells

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of CD107a (also called LAMP-1), a protein found on certain immune cells in whole blood. It may be used to assess immune cell activation or function.

Quick summary

["CD107a helps identify activated immune cells, often linked to immune responses or conditions like certain cancers or infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95191-3
Short code
CD107ab CMV CD8
Synonyms
CD107ab HLA-A1 CMV CD8 Cells # Bld FC
Category
chemistry
Sample
whole-blood
Container
Heparinized (sodium or lithium heparin) or EDTA anticoagulant tube; ACD (acid-citrate-dextrose) tubes are also acceptable for flow cytometry applications
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
86357
SNOMED
444080009
Specimen volume
5-10 mL of whole blood; minimum 3 mL for pediatric or low-volume samples
Stability
Specimen should be processed within 8-24 hours of collection when stored at room temperature (18-25°C). If processing is delayed beyond 24 hours, store at 2-8°C. Do not freeze whole blood specimens. Optimal viability is maintained when processed within 6-8 hours of collection.
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
24–72 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test to evaluate immune cell activity, particularly in conditions where immune cells are suspected of being overactive or responding to specific triggers, such as chronic inflammation, autoimmune diseases, or certain types of cancer (e.g., lymphoma). It may also be used in research or specialized clinical settings to monitor immune responses.

What to Expect Before the Test

No special preparation is typically required. You may be asked to fast or avoid certain medications, but your provider will clarify this if needed. Bring any recent medications or supplements to your appointment.

What the Test Involves

A small blood sample will be drawn from a vein, usually in your arm. The process is quick and usually causes minimal discomfort. The blood sample is then analyzed to detect CD107a on immune cells.

What the Results Mean

Results may indicate baseline levels of immune cell activation or help compare changes over time. Elevated levels could suggest heightened immune activity, while normal or low levels may indicate typical or suppressed immune responses. Your provider will discuss these results in the context of your overall health and symptoms.

Reference range

Reference ranges are laboratory-specific and depend on the HLA-A1 CMV peptide used, the stimulation protocol, and the healthy donor population. Results are typically reported as absolute counts (cells/μL) and/or percentages of CD8+ T cells. No universally established reference range exists; clinical interpretation should be based on the laboratory's validated reference interval and longitudinal patient trends.N/A

Specimen: whole-blood

No special fasting required. Patient should be well-hydrated. Recent immunosuppressive therapy, including corticosteroids, calcineurin inhibitors, and biologics, may affect results and should be documented. Avoid specimen collection during acute illness when possible, as this may transiently alter immune cell function.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

CD107a is a marker associated with the activation of certain immune cells, such as natural killer (NK) cells and some types of T cells. Elevated levels may be observed in conditions involving chronic inflammation, autoimmune diseases, or immune-related cancers. It can also be used in research settings to study immune responses to infections or vaccines.

Short name

CD107a (LAMP-1) Blood Cell Count

Frequently asked questions

How is this test different from other immune cell tests?
This test specifically measures CD107a, a protein that appears on immune cells when they are activated. Unlike general immune cell counts (e.g., white blood cell differentials), this test focuses on a particular marker tied to immune activation, which can provide more targeted insights into immune function.
What conditions might trigger an abnormal result?
Abnormal results could be seen in conditions involving chronic inflammation, autoimmune diseases (such as rheumatoid arthritis or lupus), certain infections, or immune-mediated cancers. However, results alone cannot diagnose a condition; they must be interpreted alongside clinical findings and other tests.
Can lifestyle or medications affect this test?
While lifestyle factors like diet or exercise may influence immune function indirectly, they are unlikely to directly affect CD107a levels. Some medications, particularly immunosuppressants or immune-modulating drugs, could influence immune cell activity and may require discussion with your provider if you are taking them.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy