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CD117-positive cells in bone marrow aspirate (qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of CD117-positive cells in a sample taken from your bone marrow. CD117 is a protein marker that may help identify certain blood or bone marrow conditions.

Quick summary

["This test helps doctors assess abnormal cell types in your bone marrow."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51443-0
Short code
CD117
Synonyms
CD117 Cells Bld-aCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA) or sodium heparin tube for flow cytometry. ACD anticoagulant tubes may also be acceptable.
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Flow cytometry using fluorescently labeled monoclonal antibodies against CD117 (c-KIT) surface marker, typically with side scatter and CD45 gating strategies
CPT
88184
SNOMED
395124003
Specimen volume
3-5 mL of whole blood
Stability
Specimen should be processed within 24-48 hours of collection when stored at room temperature (18-25°C). Refrigeration may affect cell viability. Best results obtained when analyzed within 24 hours of collection.
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
24–72 hours
Order
routine

What Does This Test Measure?

CD1117-positive cells are identified using a specialized laboratory technique that detects specific proteins on the surface of cells. This test is often used to detect or monitor certain blood cancers, such as acute myeloid leukemia (AML), or other hematologic disorders. The sample is analyzed to determine if these cells are present in your bone marrow fluid.

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have symptoms like fatigue, unexplained weight loss, or frequent infections. It may also be used during diagnosis, treatment planning, or monitoring of conditions affecting your blood or bone marrow.

Sample Collection and Preparation

A small amount of bone marrow is collected through a needle inserted into your hip bone. The sample is then processed in the lab to examine the cells for CD117 markers. This procedure is typically done under local anesthesia and is generally safe.

What to Expect Before the Test

No special preparation is usually needed, but inform your doctor about any medications you’re taking. You may experience mild discomfort or bruising at the injection site, but most people tolerate the procedure well.

Reference range

CD117+ mast cells and progenitor cells are not normally detected in significant quantities in peripheral blood. Results are typically reported as absent or within laboratory-specific reference limits established by flow cytometry analysis.N/A

Specimen: whole-blood

No special patient preparation required. Specimen should be collected and transported to the laboratory promptly to maintain cell viability.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

The presence of CD117-positive cells can indicate certain blood cancers or other hematologic disorders. These cells may appear abnormal or increased in number in conditions such as acute myeloid leukemia (AML) or other myeloproliferative diseases. Doctors use this test to help diagnose, stage, or monitor these conditions and guide treatment decisions.

Short name

CD117+ Cells in Bone Marrow

Frequently asked questions

How long does it take to get results from this test?
Results from this qualitative test are typically available within a few days to a week, depending on the laboratory’s workload and processing time.
What does a positive result mean?
A positive result means that CD117-positive cells were detected in your bone marrow sample. This finding may suggest an underlying blood disorder or cancer, but further testing and evaluation by your healthcare provider will be needed to determine the cause and next steps.
Can this test be used to diagnose leukemia?
While this test can help identify certain abnormal cell types, it is often used in conjunction with other tests and evaluations to diagnose leukemia or other hematologic conditions. Your doctor will consider the results alongside clinical findings and other diagnostic tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy