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Serum or plasma concentration of CD14 (monocyte-associated marker)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of CD14, a protein found on the surface of certain immune cells, including monocytes. It may be used to assess immune function or inflammation.

Quick summary

["CD14 helps your immune system respond to infections and inflammation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49465-8
Short code
CD14IHC
Synonyms
CD14 Ag Tiss Ql ImStn
Category
chemistry
Sample
serum
Container
10% Neutral Buffered Formalin (NBF) fixed, paraffin-embedded tissue block or unstained charged/positively charged glass slides (typically 4-5 micron sections). Tissue should be submitted in formalin-filled leak-proof container.
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
immune-stain
CPT
88342
SNOMED
395124008
Specimen volume
Adequate representative tissue specimen; minimum 3-4 unstained sections (4-5 μm thickness) on positively charged slides plus one H&E slide, or paraffin block suitable for sectioning.
Stability
Formalin-fixed paraffin-embedded (FFPE) tissue: stable at room temperature for years. Cut unstained slides: stable at room temperature for up to 1 year; 2-8°C preferred for long-term storage. Avoid prolonged exposure to humidity.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
48–96 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may request this test if you have symptoms of infection, autoimmune conditions, or if they suspect an immune-related issue. It could also be part of a broader evaluation for certain blood disorders or inflammatory diseases.

What to Expect Before the Test

No special preparation is usually needed. You may fast if instructed, but check with your provider. A simple blood draw is typically performed in a clinic or lab.

What the Test Results Mean

Results alone may not provide a definitive diagnosis. They are often interpreted alongside other clinical findings, symptoms, and test results. Elevated levels might suggest infection or inflammation, while lower levels could indicate immune suppression or certain genetic conditions.

Common Conditions Monitored

This test may be used to monitor conditions like sepsis, certain infections, or autoimmune diseases where immune cell activity is involved.

Reference range

Presence/absence of CD14 antigen expression in tissue. Reported as Positive or Negative. Staining intensity may be graded on a scale (e.g., 0, 1+, 2+, 3+) with pattern noted (membranous, cytoplasmic). Normal lymphoid tissues: scattered positive cells in macrophage/monocyte populations; germinal centers typically negative.N/A

Specimen: serum

No special patient preparation required for the submitted tissue specimen. Tissue collection and fixation are performed by surgical/pathology personnel prior to submission.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

CD14 is a marker that can reflect the body’s immune response. High levels may indicate an active infection or inflammatory process, while low levels could point to immune dysfunction or genetic disorders affecting immune cell function. It is often used as part of a broader diagnostic approach rather than a standalone test.

Short name

CD14 Level

Frequently asked questions

How is CD14 tested?
CD14 is measured using an immunoassay method, which detects the protein in your blood sample. The test typically uses a small blood sample drawn from your arm.
How long does it take to get results?
Test results are usually available within 1 to 3 business days, depending on your lab’s processing schedule.
Can diet or medications affect CD14 levels?
Dietary factors or certain medications may indirectly influence immune responses, but they do not typically cause significant changes in CD14 levels on their own. Always follow your provider’s advice regarding test preparation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy