CD235A (Glycoprotein IIb/IIIa) on Platelet Surface
This test measures the presence of CD235A, a glycoprotein found on the surface of platelets, which plays a role in blood clotting. It may be used to assess platelet function or detect certain blood disorders.
["Understanding CD235A levels can help diagnose or monitor conditions affecting platelet function or blood clotting mechanisms."]
Key facts at a glance
- LOINC
- 57430-1
- Short code
- CD235aBF
- Synonyms
- CD235a Cells NFr Fld
- Category
- chemistry
- Sample
- serum
- Container
- Sterile body fluid collection container; EDTA (lavender-top) tube preferred for flow cytometry analysis
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Flow cytometry using fluorescently labeled antibodies against CD235a (glycophorin A) antigen for identification and enumeration of erythroid cells in body fluids
- CPT
- 88184
- SNOMED
- 395124002
- Specimen volume
- Minimum 1-2 mL of body fluid; preferably 3-5 mL to allow for adequate cell concentration analysis
- Stability
- Specimen should be processed within 2-4 hours of collection. If delayed, store at 2-8°C for up to 24 hours. Do not freeze.
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms or conditions that could involve abnormal platelet function, such as unexplained bleeding, clotting issues, or certain blood cancers. It could also be part of a broader evaluation for inherited or acquired platelet disorders.
What to Expect Before the Test
No special preparation is typically needed. You may have a blood sample drawn from a vein in your arm, similar to other blood tests. If you’re on blood-thinning medications, let your provider know before the test.
What the Test Results Mean
Results are qualitative (present or absent) and indicate whether CD235A is detected on your platelets. Abnormal findings may suggest conditions like thrombocytopenia (low platelet count), platelet dysfunction, or other blood-related disorders.
Common Conditions Linked to CD235A Testing
This test may be part of diagnosing or evaluating conditions such as von Willebrand disease, Bernard-Soulier syndrome, or other inherited bleeding disorders. It can also help assess platelet activation in certain inflammatory or autoimmune conditions.
Reference range
Reference ranges are not well established for CD235a+ cells in body fluids. Results should be interpreted in the clinical context of the patient and type of body fluid analyzed. Generally, CD235a+ cells are scant to absent in normal non-hemorrhagic body fluids.N/A
No special patient preparation required. Fasting is not necessary for this test.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Platelet Glycoprotein IIb/IIIa Expression
Frequently asked questions
What does a positive or negative result mean?
Can this test be used to diagnose all platelet disorders?
Does fasting affect this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy