CD235a (Glycoprotein IIb/IIIa) on Platelet Surface Cells
This test measures the presence of CD235a, a glycoprotein found on the surface of platelets, which plays a key role in blood clotting. It may be used to assess platelet function or detect certain blood disorders.
["This test helps evaluate platelet surface markers that influence clotting ability."]
Key facts at a glance
- LOINC
- 33208-0
- Short code
- CD235a-BM
- Synonyms
- CD235a Cells NFr Mar
- Category
- chemistry
- Sample
- serum
- Container
- EDTA (lavender-top) or sodium heparin (green-top) tube for bone marrow aspirate; sterile collection required
- Units
- N/A
- Ref low
- 15
- Ref high
- 35
- Critical range
- 5 N/A – 50 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–99 years
- Method
- Flow cytometry immunophenotyping using CD235a (glycophorin A) monoclonal antibodies
- CPT
- 88184
- SNOMED
- 396291001
- Specimen volume
- 1-3 mL of bone marrow aspirate collected into anticoagulant tube; first-pull preferred for morphology
- Stability
- Specimen should be processed within 24 hours of collection when stored at room temperature (18-25°C); do not refrigerate as this may affect cell viability and antigen expression
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–48 hours
- Order
- routine
Why Might This Test Be Ordered?
Your healthcare provider may recommend this test if you have symptoms or conditions that could affect platelet function, such as unexplained bleeding, clotting issues, or certain blood cancers. It may also be part of a broader evaluation for inherited or acquired platelet disorders.
What Does the Test Involve?
A blood sample is drawn from a vein, typically in your arm. The sample is then analyzed to detect CD235a on your platelets. The test does not require fasting or special preparation beyond standard blood draw precautions.
Sample Collection and Processing
Whole blood is collected and processed to isolate platelets. The CD235a glycoprotein is identified using specialized laboratory techniques, such as flow cytometry, which measures the presence of specific markers on the cell surface.
What to Expect Before the Test
No special preparation is needed. You may have some mild discomfort from the needle, but it usually goes away quickly. If you are on blood-thinning medications, inform your provider before the test.
Reference range
Reported as percentage of total nucleated cells or absolute count; reference ranges vary by age and laboratory. Erythroid precursors typically represent 15-35% of nucleated cells in normal adult bone marrow.N/A
No special patient preparation required. Recent blood transfusions may affect results. Inform laboratory of recent therapy including chemotherapy, erythropoietin, or G-CSF administration.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Platelet Glycoprotein IIb/IIIa Expression
Frequently asked questions
What does a CD235a test measure?
How is the test result interpreted?
Can this test be used to diagnose all platelet disorders?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy