CD235a (Glycoprotein IIb/IIIa) on Platelet Surface
This test measures the presence of glycoprotein IIb/IIIa, a protein found on the surface of platelets, which plays a key role in blood clotting. It may be used to assess platelet function or monitor conditions affecting platelet activity.
["This test helps evaluate how well your platelets function in clotting blood, which can be important for diagnosing bleeding disorders or managing certain medications."]
Key facts at a glance
- LOINC
- 33205-6
- Short code
- CD235aPF
- Synonyms
- CD235a Cells NFr Prt
- Category
- chemistry
- Sample
- serum
- Container
- Sterile, heparinized collection tube or tube containing anticoagulant (EDTA) suitable for flow cytometry; transport at room temperature
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Flow cytometry with fluorescent-labeled antibodies against CD235a (glycophorin A)
- CPT
- 88184 (Flow cytometry, cell surface, cytoplasmic, or nuclear marker, technical component only - first marker)
- SNOMED
- 444900008 |Measurement of cells positive for CD235a in peritoneal fluid|
- Specimen volume
- 5-10 mL of peritoneal fluid; minimum 2 mL required for flow cytometric analysis
- Stability
- Process within 1-2 hours of collection; if delay anticipated, refrigerate at 2-8°C and process within 24 hours
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like easy bruising, excessive bleeding, or if you’re taking medications that affect blood clotting, such as antiplatelet drugs. It may also be used in research or specialized diagnostic settings to study platelet biology.
What to Expect Before the Test
No special preparation is typically needed. You may have a blood sample drawn from a vein in your arm, similar to other blood tests. If you’re on blood-thinning medications, let your provider know before the test.
What the Test Results Mean
The results measure the density or amount of glycoprotein IIb/IIIa on your platelets. Abnormal levels might suggest platelet dysfunction, but interpretation depends on clinical context and other test results.
Common Conditions or Medications Affecting This Test
Conditions like thrombocytopenia (low platelet count) or platelet dysfunction syndromes (e.g., Bernard-Soulier syndrome) may affect glycoprotein IIb/IIIa levels. Certain medications, such as aspirin or clopidogrel, can also influence platelet function.
Reference range
Reference range not established for peritoneal fluid. Interpretation based on clinical context; elevated CD235a+ cells may indicate intra-abdominal hemorrhage or hemolytic process.N/A
No special patient preparation required. Specimen is typically obtained during diagnostic or operative paracentesis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Platelet Glycoprotein IIb/IIIa Quantification
Frequently asked questions
What does a change in this test indicate?
How often is this test repeated?
Is this test painful?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy