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Cerebrospinal Fluid Cell Count with CSF Growth Factor (CSF-derived growth factor activity measurement)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of cells in your cerebrospinal fluid (CSF) and evaluates the presence of certain growth factors that may influence cell activity in the brain and spinal cord.

Quick summary

["Helps assess inflammation, infection, or other conditions affecting CSF and growth factor dynamics."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43949-7
Short code
CSFCD2
Synonyms
CD2 Cells # CSF
Category
chemistry
Sample
csf
Container
Sterile CSF collection tube (polypropylene); tube 3 or 4 typically preferred for cell surface marker analysis to minimize blood contamination
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Flow cytometry
CPT
86359
Specimen volume
1-3 mL of cerebrospinal fluid
Stability
Specimen should be processed within 1-2 hours of collection for optimal viability. If delay is anticipated, keep at room temperature (18-22°C) and process as soon as possible.
Hemolysis max
200
TAT
24–72 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like headaches, neck stiffness, vision changes, or neurological issues that suggest abnormalities in the CSF. It could also be part of a broader evaluation for conditions like meningitis, brain tumors, or multiple sclerosis.

What to Expect Before the Test

You’ll typically have a lumbar puncture (spinal tap) performed by a healthcare professional. This involves inserting a needle into your lower back to collect a small sample of CSF. You may feel mild pressure or discomfort, but it’s usually brief. Avoid heavy lifting or strenuous activity for 24 hours afterward.

What the Test Results Mean

The test measures cell count and growth factor activity in the CSF. Elevated cell counts may indicate inflammation, infection, or blood leakage into the CSF. Growth factor activity could be assessed for conditions affecting cell repair or proliferation in the central nervous system.

Common Conditions Monitored

This test helps diagnose or monitor conditions such as infections (e.g., bacterial or viral meningitis), autoimmune diseases (e.g., multiple sclerosis), or tumors affecting the brain or spinal cord. It may also guide treatment decisions for certain neurological disorders.

Reference range

CD2+ T cells are typically absent or present in very low numbers in normal cerebrospinal fluid. Reference ranges are laboratory-specific and generally reported as absolute count per microliter.N/A

Specimen: csf

No special preparation required. Lumbar puncture should be performed under sterile conditions by qualified personnel.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Elevated cell counts in CSF often signal inflammation, infection, or blood presence, while abnormal growth factor activity may indicate disrupted cellular processes in the central nervous system. Results are interpreted in context with symptoms, other tests, and clinical findings.

Short name

CSF Cell Count with Growth Factor Activity

Frequently asked questions

What does a normal result mean for my health?
A normal result suggests your CSF cell count and growth factor activity are within expected ranges, but it doesn’t rule out all possible causes of symptoms. Follow-up may include additional tests or monitoring based on your healthcare provider’s recommendations.
How often will I need this test?
Frequency depends on your condition and treatment plan. Your provider will determine how often you need retests, whether it’s monthly, yearly, or as needed for symptom changes.
Can I prepare differently for this test based on my condition?
If you have certain medications, infections, or conditions (e.g., bleeding disorders), inform your provider before the test. Avoid alcohol or certain medications that may affect CSF composition, as advised by your doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy