CD35 Antigen Expression in Red Blood Cells (Qualitative)
This test checks whether red blood cells (RBCs) express CD35, a protein involved in immune system function and blood health. It may be used to evaluate conditions affecting RBCs or immune responses.
["CD35 helps regulate blood clotting and immune responses; low levels may signal underlying health concerns."]
Key facts at a glance
- LOINC
- 13346-2
- Short code
- CD35
- Synonyms
- CD35 Cells NFr Bld
- Category
- chemistry
- Sample
- whole-blood
- Container
- EDTA (lavender-top) tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Flow cytometry
- CPT
- 86356
- SNOMED
- 399142005
- Specimen volume
- 3-5 mL whole blood
- Stability
- Process within 24-48 hours of collection; store at room temperature (18-25°C); do not refrigerate
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 24–72 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like fatigue, anemia, or immune-related issues. It could also be part of a broader evaluation for conditions like autoimmune disorders, blood disorders, or certain infections.
What to Expect Before the Test
No special preparation is needed. You may have a simple blood draw, similar to other routine blood tests. If you’re on blood thinners or have a history of bleeding disorders, let your provider know.
What the Results Mean
Results are qualitative (positive/negative) rather than numerical. A positive result means RBCs express CD35, while a negative result may indicate abnormal RBC function or immune activity. Your provider will discuss findings in the context of your health.
Common Conditions Monitored
This test may help diagnose or monitor conditions like hereditary spherocytosis, autoimmune hemolytic anemia, or other RBC-related disorders. It can also support research into immune system interactions with blood cells.
Reference range
Reference ranges vary by laboratory; typically reported as percentage and absolute count of CD35-positive lymphocytesN/A
No special preparation required
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical significance: CD35 is a complement receptor on RBCs that helps clear immune complexes and regulate inflammation. Deficiencies or altered expression may correlate with hemolytic anemia, immune dysfunction, or other hematologic disorders. Results guide targeted follow-up or treatment planning.
Short name
CD35 RBCs
Frequently asked questions
What does a positive result mean?
Can this test detect infections?
Does this test require fasting?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy