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CD3+ T Cell Count (Absolute)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of CD3+ T cells in your blood, which are a type of white blood cell important for immune function.

Quick summary

["CD3+ T cells help fight infections and regulate immune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
107083-8
Short code
CD3CD26
Synonyms
CD3+CD26+ Cells NFr Bld FC
Category
chemistry
Sample
whole-blood
Container
EDTA (lavender/purple-top) anticoagulant tube; ACD (yellow-top) tube is also acceptable
Units
N/A
Ref low
5
Ref high
15
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
86359
SNOMED
396881000
Specimen volume
3-5 mL of whole blood; minimum 1 mL for pediatric samples
Stability
Specimen should be processed within 24-30 hours of collection when stored at room temperature (18-25°C). Refrigeration (2-8°C) may extend stability to 48 hours but may affect some surface marker expression. Do not freeze.
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
24–72 hours
Order
routine

What Are CD3+ T Cells?

CD3+ T cells are a subset of lymphocytes (a type of white blood cell) that play a central role in the immune system. They help identify and destroy pathogens like viruses and bacteria, as well as regulate other immune responses. CD3 is a protein marker found on all T cells, making this test useful for assessing overall T cell activity.

Why Might You Need This Test?

Doctors may order a CD3+ T cell count to evaluate immune function, diagnose conditions like immunodeficiency, or monitor treatment responses in diseases such as HIV, autoimmune disorders, or certain cancers. It can also help assess how well your immune system is responding to infections or medications.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then analyzed in a lab to count the number of CD3+ T cells present. This test is typically done using flow cytometry, a technique that separates and counts different types of blood cells based on their markers.

What Do Results Mean?

Results are usually reported as a count of CD3+ T cells per microliter (cells/µL) of blood. Lower than expected counts may indicate immune deficiencies or conditions affecting T cell production or function. Higher counts may sometimes be seen in certain infections or inflammatory states, but this is less common.

Reference range

Reference values for CD3+CD26+ cells in peripheral blood vary by laboratory and reporting unit (cells/μL or percentage of lymphocytes). Typical adult ranges: 5-15% of total lymphocytes or 80-400 cells/μL. Pediatric values are generally higher than adult values.N/A

Specimen: whole-blood

No special preparation required. Patients should inform their healthcare provider of any recent corticosteroid, immunosuppressive, or immunomodulatory therapy, as these may affect lymphocyte subset counts. Recent vaccinations may transiently alter results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

CD3+ T Cells

Frequently asked questions

How often will I need this test?
The frequency depends on your medical condition. If you have an immune disorder, HIV, or are undergoing immunotherapy, your doctor may recommend regular monitoring. Otherwise, this test is usually only done if symptoms or other test results suggest an issue with your immune system.
What are the normal ranges?
Normal ranges can vary slightly between labs, but generally, CD3+ T cell counts range from about 500 to 2,000 cells per microliter of blood. Your doctor will interpret results in the context of your overall health and medical history.
Can lifestyle changes affect this test?
Yes, certain lifestyle factors like stress, poor sleep, or chronic illnesses can influence immune cell counts. Avoiding extreme stress, maintaining a balanced diet, and staying hydrated may support overall immune health, but this test specifically measures absolute cell counts and may not be directly affected by lifestyle changes alone.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy