CD59 Protein in Cerebrospinal Fluid (CSF)
This test measures the level of CD59, a protein found in cerebrospinal fluid (the fluid surrounding the brain and spinal cord), which helps protect cells from damage caused by the immune system. It may be used to evaluate conditions affecting the central nervous system.
["CD59 in CSF can help diagnose or monitor certain neurological or immune-related disorders."]
Key facts at a glance
- LOINC
- 51357-2
- Short code
- CD59CSF
- Synonyms
- CD59 Cells NFr CSF
- Category
- chemistry
- Sample
- csf
- Container
- Sterile CSF collection tube, polypropylene, screw-cap
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Flow cytometry
- CPT
- 86356
- SNOMED
- 313230004
- Specimen volume
- 1-2 mL of cerebrospinal fluid
- Stability
- Refrigerated (2-8°C): up to 24 hours; Do not freeze. Process and analyze as soon as possible after collection to preserve cell viability for flow cytometry.
- Hemolysis max
- 200
- TAT
- 24–72 hours
- Order
- routine
When Is This Test Ordered?
Your healthcare provider may order this test if you have symptoms like headaches, neurological issues, or signs of an immune response in the brain. It could also be part of a broader evaluation for conditions such as multiple sclerosis, infections, or inflammatory diseases of the nervous system.
What Does a Result Mean?
CD59 levels in CSF can vary depending on health conditions. Abnormal results may suggest immune-mediated damage, infections, or other neurological disorders. Your doctor will interpret the results in the context of your symptoms and medical history.
How Is the Test Performed?
A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then analyzed in a lab to measure CD59 levels.
What Are Possible Causes of Abnormal Results?
Elevated or decreased CD59 in CSF could be linked to conditions such as autoimmune diseases, infections (like meningitis), or certain neurological disorders. Always discuss your results with your healthcare provider for personalized insights.
Reference range
Reference ranges vary by laboratory; CD59 expression is typically reported as percentage of cells expressing the marker. Normal cells demonstrate complete (bright) CD59 expression. Results should be interpreted in conjunction with CD55 and other PNH clone markers.N/A
No fasting required. Lumbar puncture should be performed under sterile conditions by qualified personnel. Inform the laboratory of any recent immunosuppressive therapy.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
CD59 in CSF is primarily used to assess immune activity or damage in the central nervous system. It may help diagnose conditions like Guillain-Barré syndrome, demyelinating diseases, or other inflammatory processes affecting the brain and spinal cord.
Short name
CSF CD59
Frequently asked questions
Why might my doctor request this test?
How long does it take to get results from this test?
Is there anything I should do to prepare for this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy