Monocyte CD59 Protein Level (Serum/Plasma)
This test measures the presence of CD59 protein on monocytes, a type of white blood cell. CD59 helps protect cells from damage by the immune system.
["CD59 on monocytes may be checked if you have symptoms of immune-related conditions or after receiving certain treatments."]
Key facts at a glance
- LOINC
- 60554-3
- Short code
- CD59MONO
- Synonyms
- CD59 deficient Monocytes NFr Bld
- Category
- chemistry
- Sample
- whole-blood
- Container
- EDTA (lavender-top) tube; sodium heparin (green-top) tube also acceptable for flow cytometry
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Flow cytometry
- CPT
- 88184
- SNOMED
- 395124003
- Specimen volume
- 3-5 mL of whole blood
- Stability
- Specimen must be processed within 24-48 hours of collection; store at room temperature (18-25°C); do not refrigerate as this may affect cell viability and marker expression
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 24–72 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have signs of immune system dysfunction, such as chronic inflammation, autoimmune diseases, or after receiving immunosuppressive therapies. It may also be used to monitor treatment response or diagnose rare genetic conditions affecting monocyte function.
What to Expect Before the Test
No special preparation is needed. You may have a blood sample drawn from a vein in your arm, similar to other routine blood tests. If you’re on blood thinners, let your provider know before the test.
What the Results Mean
Results are qualitative (present or absent) and compare CD59 protein levels on your monocytes to a standard reference. Low levels may indicate impaired immune regulation or genetic disorders affecting cell membranes.
Common Conditions Monitored
This test is often used in research or specialized clinical settings to assess conditions like paroxysmal nocturnal hemoglobinuria (PNH), where CD59 deficiency on red blood cells is well-known. Its use in routine care is limited.
Reference range
Normal expression of CD59 on monocytes and other blood cells; absence or marked deficiency indicates paroxysmal nocturnal hemoglobinuria (PNH) cloneN/A
No fasting required. Avoid recent blood transfusion (within 4 weeks) as it may affect interpretation. Inform laboratory of recent transfusion history.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
CD59 Monocyte Test
Frequently asked questions
Will this test be done at home?
How long will I need to wait for results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy