Clostridium difficile Toxin A and B (Qualitative) in Stool

What Is *Clostridium difficile* Infection?

*Clostridium difficile* (often called *C. diff*) is a germ that can cause diarrhea, abdominal pain, and sometimes life-threatening complications if it spreads beyond the intestines. It usually spreads through contaminated surfaces or contact with infected people, especially in healthcare settings. This test checks for toxins A and B, which are harmful substances the bacteria releases to harm the gut lining.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like severe diarrhea (watery or bloody), abdominal pain, or fever after recent antibiotic use—especially broad-spectrum antibiotics like clindamycin, ampicillin, or fluoroquinolones. It’s also used in hospitals to diagnose infections in patients who’ve recently been treated with antibiotics or had gut procedures.

What Does a Positive Result Mean?

A positive result means your stool contains toxins A and B from *C. diff*. This confirms the infection and helps guide treatment, such as stopping antibiotics that may have worsened it or starting medications to kill the bacteria or reduce its harmful effects.

How Is the Test Done?

You’ll provide a fresh stool sample (usually collected in a special container) to be tested in the lab. The test looks for toxins in the stool using a sensitive immunoassay method to detect their presence without measuring exact amounts.