Cerebrospinal fluid (CSF) total protein mass concentration
This test measures the total protein content in your cerebrospinal fluid, which is the fluid surrounding your brain and spinal cord. Protein levels can help identify issues like inflammation, infections, or blood leaks in the central nervous system.
["Protein in CSF may signal brain or spinal cord problems."]
Key facts at a glance
- LOINC
- 2037-0
- Short code
- CEACSF
- Synonyms
- CEA CSF-mCnc
- Category
- chemistry
- Sample
- csf
- Container
- Sterile CSF collection tube (polypropylene), tube #2 or #3 of collected fractions to minimize blood contamination
- Units
- N/A
- Ref low
- 0
- Ref high
- 5
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Immunoassay (chemiluminescent or enzyme-linked)
- CPT
- 86316
- SNOMED
- 395125005
- Specimen volume
- 1-2 mL of cerebrospinal fluid
- Stability
- Room temperature: 2 hours; Refrigerated (2-8°C): 24 hours; Frozen (-20°C or below): up to 3 months for prolonged storage
- Hemolysis max
- 200
- TAT
- 24–72 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you have symptoms like headaches, neck stiffness, confusion, or neurological issues. It could also be used to diagnose conditions such as meningitis, multiple sclerosis, or other brain-related disorders.
What to Expect Before the Test
You’ll likely have a small needle inserted into your back to collect a sample of CSF. This is usually done in a hospital or clinic setting. The procedure is quick but may cause mild discomfort. No special preparation is needed.
What the Results Mean
Elevated protein levels in CSF might indicate inflammation, infection, or bleeding into the brain. Lower-than-expected levels could suggest certain genetic or metabolic conditions. Your doctor will interpret results in relation to your symptoms and medical history.
Common Conditions Linked to CSF Protein Levels
High protein levels can be linked to conditions like Guillain-Barré syndrome, subarachnoid hemorrhage, or certain types of brain tumors. Low levels may be associated with conditions such as cerebral salt-wasting syndrome or certain genetic disorders.
Reference range
Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A
No fasting required. Lumbar puncture should be performed under standard aseptic technique by qualified personnel. Informed consent is required for the procedure.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
CSF Protein Level
Frequently asked questions
Will I need to fast before this test?
How long will it take to get my results?
Can I drink fluids right before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy