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C-reactive protein, serum/plasma mass concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of C-reactive protein, a protein produced by the liver in response to inflammation in your body.

Quick summary

["CRP helps doctors assess inflammation, often used to monitor conditions like infections, autoimmune diseases, or after surgery."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10560-1
Short code
CEASEM
Synonyms
CEA Smn-aCnc
Category
chemistry
Sample
serum
Container
Sterile, wide-mouthed specimen container (semen collection container)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
male
Age range
18–99 years
Method
Immunoassay (Chemiluminescent or Electrochemiluminescent)
CPT
86301
SNOMED
104734006
Specimen volume
1-2 mL of ejaculate
Stability
Room temperature: 1 hour; Refrigerated (2-8°C): 24 hours; Frozen (-20°C or lower): 1 month. Avoid repeated freeze-thaw cycles.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order a CRP test to check for signs of inflammation, monitor chronic conditions like rheumatoid arthritis or lupus, evaluate infections, or assess how well you’re healing after surgery or an injury.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Higher CRP levels often indicate inflammation, but the exact meaning depends on your overall health and symptoms. Elevated levels may prompt further testing or treatment adjustments.

Common Conditions Monitored

CRP is commonly used to track conditions like infections (e.g., pneumonia, urinary tract infections), autoimmune diseases (e.g., rheumatoid arthritis), or to evaluate responses to treatments.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

Patient should abstain from ejaculation for 2-5 days prior to specimen collection. Specimen should be collected in a sterile, wide-mouthed container. Maintain specimen at body temperature and deliver to laboratory within 1 hour of collection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CRP (Serum/Plasma)

Frequently asked questions

What causes CRP levels to change?
CRP levels can rise due to infections (bacterial, viral), injuries, surgeries, or autoimmune diseases. Stress, certain medications, or pregnancy may also affect results.
How often should I get this test?
Your provider will determine the frequency based on your health needs. Some people get CRP tests every few months for chronic conditions, while others may need it only occasionally.
Can diet or exercise affect CRP levels?
Yes, lifestyle factors like diet (e.g., Mediterranean diet), exercise, and weight management can influence CRP levels. Reducing inflammation may lower CRP over time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy