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C-reactive protein (high-sensitivity) in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein produced by the liver in response to inflammation, helping assess low-grade inflammation or risk of cardiovascular events.

Quick summary

["hsCRP helps track subtle inflammation that may not show up in other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10469-5
Short code
CEATISS
Synonyms
CEA Tiss Ql ImStn
Category
chemistry
Sample
serum
Container
10% neutral buffered formalin container for tissue fixation; paraffin-embedded tissue block (FFPE) for processed specimens
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
immune-stain
CPT
88342
SNOMED
10828-0
Specimen volume
Tissue biopsy or excisional specimen; minimum 5x5x5 mm fresh tissue recommended for adequate fixation and staining
Stability
Fresh tissue: stable in 10% neutral buffered formalin for 24-48 hours at room temperature (15-25°C). FFPE blocks: stable indefinitely at room temperature. Cut tissue sections: stable for 6 months at 2-8°C.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

Why hsCRP Matters for Your Health

hsCRP (high-sensitivity C-reactive protein) is a marker for inflammation in your body. While acute inflammation (like an infection) raises hsCRP sharply, chronic or low-level inflammation—such as from conditions like arthritis, heart disease, or metabolic issues—may show up more subtly. Your doctor may use this test to monitor risk over time or guide treatment decisions.

What Does a High or Low hsCRP Level Mean?

A higher-than-normal hsCRP level suggests increased inflammation, which can signal underlying health concerns like heart disease, autoimmune conditions, or other chronic illnesses. A very low level typically means minimal inflammation. However, results alone don’t diagnose a condition—they’re used alongside other factors.

Common Reasons for Testing

Doctors may order hsCRP to evaluate cardiovascular risk, especially if you have risk factors like high blood pressure, diabetes, or a family history of heart disease. It’s also used in monitoring conditions like rheumatoid arthritis or after treatments like chemotherapy to check for inflammation.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample (serum or plasma) during a routine lab visit. Avoid strenuous activity or heavy meals 24 hours before testing, as they might affect results.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No patient preparation required. Tissue specimens are collected via surgical excision or biopsy procedures performed by qualified medical personnel.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

hsCRP is a key tool in cardiovascular risk assessment. Elevated levels are associated with higher risks of heart attacks, strokes, and other vascular events, particularly in people with risk factors like high cholesterol or diabetes. It’s often used to guide lifestyle changes, medications (e.g., statins), or preventive strategies. However, it’s not a standalone test—your doctor will consider your overall health profile.

Short name

hsCRP

Frequently asked questions

How often should I get this test?
Your doctor will determine the frequency based on your health status and risk factors. For example, people with heart disease or diabetes may get it every few months, while others might have it once a year or less.
Can diet or exercise affect hsCRP levels?
Yes! Diet rich in fruits, vegetables, and omega-3s (like fish) can lower inflammation, while processed foods and sugar may raise it. Regular physical activity also helps reduce hsCRP levels over time.
What if my hsCRP is in the normal range but I still feel unwell?
A normal hsCRP level doesn’t rule out inflammation. Other tests (like blood counts, imaging, or physical exams) may be needed to identify causes of your symptoms, such as infections, autoimmune diseases, or other conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy