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Cefpodoxime Probenecid Concentration in Urine (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a specific antibiotic (cefpodoxime) and its companion compound (probenecid) in your urine. It helps assess how your body processes these medications.

Quick summary

["This test helps doctors check if your kidneys are working properly and how your body handles certain antibiotics."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
90849-1
Short code
CEFPODOX
Synonyms
Cefpodoxime Islt Slgr Mcbct AB 4.0
Category
chemistry
Sample
serum
Container
Sterile leak-proof specimen container; mycobacterial culture isolate on solid media (Lowenstein-Jensen or Middlebrook 7H10/7H11 agar) or in liquid broth (Middlebrook 7H9); transport in biohazard-compliant packaging
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
method-for-slow-growing-mycobacteria-antibiotic-concentration-at-ug-ml
CPT
87188
SNOMED
394670007
Specimen volume
Pure culture isolate of slow-growing mycobacteria; minimum 1 mL liquid culture or visible colonies on solid medium
Stability
Stable for 24-48 hours at room temperature (15-25°C); refrigerate at 2-8°C if processing delayed beyond 48 hours; do not freeze mycobacterial cultures
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
336–720 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you’re taking cefpodoxime (an antibiotic) and probenecid (used to help kidneys excrete drugs) to monitor kidney function or drug levels in your urine. It could also be part of a broader evaluation for infections or kidney-related conditions.

What to Expect Before the Test

No special preparation is needed, but you may be asked to collect a urine sample at home or in a lab. Follow any instructions your doctor provides to ensure accurate results.

What the Test Results Mean

Results show the concentration of cefpodoxime and probenecid in your urine. Higher-than-expected levels might indicate kidney issues or improper medication processing, while normal levels suggest your body is handling the drugs as intended.

Common Reasons for Testing

This test is often used to diagnose kidney problems, confirm antibiotic effectiveness, or assess how well probenecid is helping your kidneys remove drugs from your system.

Reference range

Interpretive criteria based on CLSI M24 guidelines: Susceptible (S), Intermediate (I), or Resistant (R) at antibiotic concentration of 4.0 ug/mL. Breakpoints specific to slow-growing mycobacterial species including Mycobacterium tuberculosis complex, M. avium complex (MAC), and other non-tuberculous mycobacteria (NTM).N/A

Specimen: serum

No special patient preparation required. Specimen should be collected prior to next dose of antimicrobial therapy when possible to reflect baseline organism susceptibility.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal results may signal kidney dysfunction, which could affect how your body processes medications. High levels of cefpodoxime or probenecid could indicate impaired kidney clearance, while low levels might suggest insufficient drug absorption or metabolism. Regular monitoring helps prevent complications from antibiotic use.

Short name

Urine Cefpodoxime with Probenecid

Frequently asked questions

What does a positive or abnormal result mean?
An abnormal result doesn’t necessarily mean you have a problem, but it may prompt further testing. Your doctor will discuss findings with you and decide if additional steps are needed, such as adjusting medications or evaluating kidney health.
Can I drink water before the test?
Yes, you can drink water normally unless instructed otherwise. Avoid excessive fluids that could dilute the sample too much, as this might affect test accuracy.
How long will I need to wait for results?
Results are typically available within a few days to a couple of weeks, depending on your lab’s processing time. Your doctor will contact you once they have the findings.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy