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Antimicrobial Activity Test: Ceftazidime/Avibactam Combination Against Vibrio Species (Qualitative Disk Diffusion)

Published: August 9, 2026Updated: August 16, 2026

This test checks whether certain bacteria in your sample, likely from a blood or fluid source, are sensitive to the antibiotic combination ceftazidime and avibactam. It helps determine if this treatment could be effective against infections caused by *Vibrio* bacteria.

Quick summary

["This test helps guide antibiotic choices for infections suspected to involve *Vibrio* bacteria, ensuring targeted treatment if needed."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101483-6
Short code
CAZAVI MIC VOC
Synonyms
cefTAZidime+Avibactam Bld Pos MIC.VOC det
Category
chemistry
Sample
whole-blood
Container
Positive blood culture bottle (aerobic and/or anaerobic) approved for continuous monitoring blood culture systems (e.g., BACTEC, BacT/ALERT). Subcultures performed on solid media including blood agar, MacConkey agar, and chocolate agar as appropriate
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
mic-voc-detection
CPT
87181
SNOMED
363548003
Specimen volume
Standard blood culture volume: 8-10 mL per bottle for adults, 1-3 mL per bottle for pediatric patients. For direct susceptibility testing from positive bottles, 1-2 mL of positive blood culture broth is required for MIC.VOC testing
Stability
Blood culture bottles: stable at room temperature (18-25°C) for up to 5 days per continuous monitoring protocol. Positive broth samples for VOC testing should be processed within 8 hours of positivity to ensure accurate organism viability. Do not refrigerate or freeze positive blood culture specimens
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms of a *Vibrio* infection (e.g., fever, gastrointestinal upset) or if you’ve been exposed to contaminated water/food. It’s particularly useful in settings like travel, shellfish consumption, or recent travel to areas with known *Vibrio* outbreaks.

How the Test Works

A small antibiotic disk (ceftazidime/avibactam) is placed on a culture of your sample. If bacteria grow around the disk, it suggests they may be resistant to this antibiotic. If no growth appears, the bacteria are likely sensitive.

What to Expect Before the Test

No special preparation is needed unless instructed by your provider. The sample (likely blood or fluid) is collected via standard lab procedures. Results are qualitative (yes/no) rather than a precise measurement.

What the Results Mean

A positive result (growth around the disk) indicates potential resistance to ceftazidime/avibactam. A negative result suggests susceptibility. Results guide whether this antibiotic should be considered for treatment.

Reference range

Interpretive categories per CLSI M100 or EUCAST breakpoints: Susceptible (S), Susceptible-Dose Dependent (SDD), Intermediate (I), or Resistant (R). Ceftazidime-avibactam CLSI breakpoints for Enterobacterales: S ≤8/4 mcg/mL, SDD 16/4 mcg/mL, R ≥32/16 mcg/mL; for Pseudomonas aeruginosa: S ≤8/4 mcg/mL, R ≥16/4 mcg/mLN/A

Specimen: whole-blood

No fasting required. Specimen should be collected prior to initiation of antimicrobial therapy when possible, or at trough levels for patients already on antibiotics. Ensure proper skin antisepsis and aseptic technique to prevent contamination. Blood should be drawn during febrile episodes or at the time of suspected bacteremia for optimal organism recovery

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test helps identify if *Vibrio* infections may require ceftazidime/avibactam therapy, reducing unnecessary antibiotic use and improving infection management. It’s critical for patients with travel-related illnesses or those at higher risk (e.g., immunocompromised individuals).

Short name

Vibrio spp. Antibiotic Susceptibility Test (Ceftazidime/Avibactam)

Frequently asked questions

What does a positive result mean?
A positive result means bacteria in your sample may be resistant to ceftazidime/avibactam, so alternative antibiotics may be needed. Your provider will discuss further treatment options.
How long does it take to get results?
Results are typically available within 24–48 hours, depending on lab processing times. Your provider will contact you once results are ready.
Can I eat or drink before this test?
No special diet is required. However, follow any general lab instructions your provider gives, such as fasting or avoiding certain medications, if applicable.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy