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Antibiotic Resistance Detection: Ceftolozane/Tazobactam Combination (Qualitative) in Body Fluids

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of bacterial resistance to ceftolozane and tazobactam, a combination antibiotic used to treat serious infections like those caused by certain bacteria like *Escherichia coli* or *Proteus*. It helps determine if your infection may not respond to this treatment.

Quick summary

This test helps doctors choose the best antibiotic to treat your infection safely and effectively.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101484-4
Short code
CFT/TZ MIC
Synonyms
Ceftolozane+Tazobactam BldPos MICVOC det
Category
chemistry
Sample
whole-blood
Container
Positive blood culture bottle (aerobic or anaerobic) flagged positive by continuous-monitoring blood culture system (e.g., BACTEC, BacT/ALERT)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
mic-voc-detection
CPT
87186
SNOMED
104376006
Specimen volume
3-10 mL of blood per culture bottle (standard adult); 1-3 mL for pediatric bottles. Sub-aliquot drawn directly from positive bottle for VOC-MIC testing.
Stability
Blood culture bottles: stable at room temperature (18-25°C) for up to 5 days from collection until flagged positive. Once positive, testing should be initiated as soon as possible; specimens are stable at room temperature for up to 24 hours after positivity flag.
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–8 hours
Order
routine

This test helps your healthcare provider look for signs of illness, check how well a treatment is working, or screen for a condition before symptoms appear. It may be ordered during a routine checkup or when you have symptoms that need a closer look.

Your doctor may order this test if you have a suspected infection that could be caused by bacteria resistant to common antibiotics. Ceftolozane/tazobactam is often used for infections like urinary tract infections, bloodstream infections, or complicated intra-abdominal infections. The test helps ensure the antibiotic you receive is effective against the bacteria causing your infection.

This test measures specific substances in your body, such as cells, proteins, hormones, or other markers. These measurements show how well certain organs are working and whether an infection, inflammation, or disease may be present.

This test detects whether bacteria in your body produce enzymes that break down ceftolozane/tazobactam, a process that makes the antibiotic less effective. The test is qualitative, meaning it only tells you if resistance is present or not, rather than measuring the exact level of resistance.

A trained healthcare professional will collect your sample, which may be a small amount of blood, urine, saliva, or a swab, depending on the type of test. The sample is then sent to a laboratory, where specially trained staff analyze it using standard methods. The collection itself is usually quick and causes little discomfort.

The test can be performed on various body fluids, including blood, urine, or cerebrospinal fluid, depending on where the infection is located. A healthcare provider will collect a sample, which is then analyzed in a lab using a method that detects the presence of resistance-related enzymes. The result is typically available within a few days.

Your results show whether the measured values fall within the normal range for this test. A normal result usually means no sign of the condition being tested for, while an abnormal result does not automatically mean you are ill. Your provider will explain what your specific results mean and whether any follow-up testing or treatment is needed.

If the test is positive, it suggests that the bacteria causing your infection may not be fully sensitive to ceftolozane/tazobactam. This means your doctor may need to choose a different antibiotic. If the test is negative, it indicates that the bacteria are likely sensitive to this antibiotic, supporting its use in treatment.

Reference range

Interpretive categories based on CLSI M100 / EUCAST breakpoints for Ceftolozane/Tazobactam: Susceptible (S) ≤4/4 µg/mL, Susceptible-Dose Dependent (SDD) 8/4 µg/mL, Intermediate (I) 16/4 µg/mL, Resistant (R) ≥32/4 µg/mL. MIC reported in µg/mL.N/A

Specimen: whole-blood

No special patient preparation required. Specimen should be collected prior to next dose of antimicrobial therapy when clinically feasible to avoid false-susceptible results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Ceftolozane/Tazobactam Resistance Screening

Frequently asked questions

Antibiotic resistance is a growing concern in healthcare. Detecting resistance to ceftolozane/tazobactam helps prevent unnecessary use of this antibiotic, reducing the risk of further resistance development. It also ensures that patients receive the most appropriate treatment, improving outcomes and reducing the risk of complications.
What happens if my test result comes back positive, and what should I expect to happen next?
If your test result is positive, your doctor will likely adjust your treatment plan. They may prescribe a different antibiotic that is more effective against the bacteria causing your infection. This adjustment helps ensure you receive the best possible care and reduces the risk of the infection becoming resistant to multiple antibiotics.
How long will it usually take to receive my results after my sample has been collected and sent to the laboratory?
The results of this test are typically available within 2 to 5 business days, depending on the lab’s processing time and any additional confirmatory testing required.
Yes, you may have already been prescribed antibiotics before this test. However, if you have not yet started them, your doctor may still want to perform this test to guide treatment decisions. Always follow your healthcare provider’s instructions regarding any medications you take before testing.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy