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Cefuroxime (Parenteral) Concentration in Blood

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of the antibiotic cefuroxime in your blood. It helps doctors determine if the drug is working properly and at the right level in your system.

Quick summary

This test helps guide antibiotic dosing and monitor treatment effectiveness.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6999-7
Short code
CFRX-P-S
Synonyms
Cefuroxime Parenter Islt Grad strip
Category
chemistry
Sample
serum
Container
Sterile transport container or appropriate culturette swab transport system depending on specimen source
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
gradient-strip
CPT
87181
SNOMED
104201000119100
Specimen volume
Variable based on specimen source; minimum quantity sufficient for pure culture isolate testing
Stability
Isolated organism plates should be tested within 24 hours of achieving adequate growth. Pure culture isolates stable on appropriate media at 2-8°C for up to 7 days.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you’re receiving intravenous (IV) cefuroxime for an infection, such as a bacterial infection requiring strong antibiotic treatment. It helps ensure the drug is at an effective concentration to fight the infection without causing harmful side effects.

What Does the Result Mean?

Results are typically reported as a concentration in micrograms per milliliter (mcg/mL) or milligrams per liter (mg/L). While specific ranges vary by lab and patient factors, your provider will interpret the result in the context of your treatment plan. Low levels may indicate the drug isn’t working well, while very high levels could signal toxicity.

How Is the Test Performed?

A blood sample is drawn from a vein (usually in your arm) by a healthcare professional. The blood is then sent to a lab for testing using a method like immunoassay or chemiluminescent immunoassay (CLIA), which detects the presence of cefuroxime.

What Should You Expect Before the Test?

No special preparation is usually needed. You may feel slight discomfort or bruising at the injection site, but this is normal. If you’re on other medications or have allergies, let your provider know before the test.

Reference range

Interpretive criteria per CLSI M100 guidelines: Susceptible ≤ 8 mcg/mL, Intermediate 16 mcg/mL, Resistant ≥ 32 mcg/mL for parenteral cefuroxime. Results vary by organism and infection site.N/A

Specimen: serum

No patient preparation required. Specimen should be collected prior to next antibiotic dose for accurate susceptibility results when possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Cefuroxime is a second-generation cephalosporin antibiotic used to treat a variety of bacterial infections. Monitoring its blood levels helps prevent resistance, optimize dosing, and reduce the risk of side effects like kidney damage or allergic reactions. Your provider may adjust your treatment based on these results if needed.

Short name

Cefuroxime Level

Frequently asked questions

How often will I need this test?
The frequency depends on your treatment plan. For short-term IV use, tests may be done at specific intervals (e.g., every 6–12 hours) to check levels. For long-term or ongoing treatment, your provider will determine the best timing based on your condition and response.
Will I experience any side effects from the blood draw?
Most people experience mild discomfort or a small bruise at the injection site. Rarely, there may be swelling or pain. If you feel dizzy, faint, or have other unusual symptoms, contact your provider immediately.
Can I eat or drink before this test?
You can eat and drink normally before the test unless your provider instructs otherwise. Avoiding food or fluids for long periods isn’t necessary for this test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy